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  Memory impairment in Parkinson's disease: The retrieval versus associative deficit hypothesis revisited and reconciled

Bezdicek, O., Ballarini, T., Buschke, H., Růžička, F., Roth, J., Albrecht, F., et al. (2019). Memory impairment in Parkinson's disease: The retrieval versus associative deficit hypothesis revisited and reconciled. Neuropsychology, 33(3), 391-405. doi:10.1037/neu0000503.

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Genre: Journal Article


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Bezdicek, Ondrej 1, Author
Ballarini, Tommaso2, Author           
Buschke, Herman3, Author
Růžička, Filip 1, Author
Roth, Jan1, Author
Albrecht, Franziska2, Author           
Ruzicka, Evžen 1, Author
Mueller, Karsten4, Author           
Schroeter, Matthias L.2, 5, Author           
Jech, Robert1, Author
1Department of Neurology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Albert Einstein College of Medicine, Yeshiva University, New York, NY, USA, ou_persistent22              
4Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              


Free keywords: Memory impairment; Mild cognitive impairment; Parkinson's disease; Resting-state functional MRI
 Abstract: Objective: Our study explored the retrieval deficit and the associative deficit hypotheses of memory impairments in Parkinson's disease (PD). The former supports a memory deficit mediated by attention/executive dysfunctions, whereas the latter hypothesizes a hippocampal memory impairment in PD. Method: We studied 31 controls and 34 PD patients classified as PD with normal cognition (PD-NC; n = 18) and PD with mild cognitive impairment (PD-MCI; n= 16). To test the retrieval deficit hypothesis, we measured the performance in encoding, retention, and recognition in verbal and visual domains; to test the associative deficit hypothesis, we used a specific associative binding measure. Using resting-state functional-MRI, we compared the functional connectivity of different hippocampal subfields between PD patients and controls, and we related it to memory performance. Results: Consistently with the retrieval deficit hypothesis, PD-MCI, and PD-NC, were impaired in free recall encoding and retention in comparison to controls, especially in the visual domain. However, as predicted by the associative deficit hypothesis, PD-MCI and, to a lesser extent, PD-NC, showed also significant associative and binding deficits in cued recall. Notably, PD patients compared to controls did not show structural differences, although they had lower connectivity between the anterior hippocampi and the precuneus/superior parietal cortex. Worse performance in memory was associated with a more severe disruption of the hippocampal connectivity. Conclusions: The pervasive pattern of memory impairment in PD supports both hypotheses. The interplay between the hippocampus, related to associative memory deficits, and the precuneus, related to attentional control, provides a neural signature that reconciles them.


Language(s): eng - English
 Dates: 2018-08-202018-03-272018-08-202019-032019-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1037/neu0000503
PMID: 30816784
 Degree: -



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Project information

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Project name : -
Grant ID : 16-13323S
Funding program : -
Funding organization : Czech Science Foundation “Micro and Macro-Connectomics of the STN nucleus”
Project name : -
Grant ID : 16-01781S
Funding program : -
Funding organization : Czech Science Foundation “Cognitive Predictors of Neurodegeneration”
Project name : Czech Republic Progres Q27/LF1
Grant ID : -
Funding program : -
Funding organization : Charles University
Project name : -
Grant ID : PDF-IRG-1307
Funding program : -
Funding organization : Parkinson’s Disease Foundation
Project name : -
Grant ID : MJFF- 11362
Funding program : -
Funding organization : Michael J. Fox Foundation
Project name : German Consortium for Frontotemporal Lobar Degeneration
Grant ID : O1GI1007A
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)

Source 1

Title: Neuropsychology
Source Genre: Journal
Publ. Info: Philadelphia, PA : American Psychological Association (PsycARTICLES)
Pages: - Volume / Issue: 33 (3) Sequence Number: - Start / End Page: 391 - 405 Identifier: ISSN: 0894-4105
CoNE: https://pure.mpg.de/cone/journals/resource/954925559517