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  Atrophy in midbrain & cerebral/cerebellar pedunculi is characteristic for progressive supranuclear palsy: A double-validation whole-brain meta-analysis

Albrecht, F., Bisenius, S., Neumann, J., Whitwell, J., & Schroeter, M. L. (2019). Atrophy in midbrain & cerebral/cerebellar pedunculi is characteristic for progressive supranuclear palsy: A double-validation whole-brain meta-analysis. NeuroImage: Clinical, 22: 101722. doi:10.1016/j.nicl.2019.101722.

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Albrecht_Bisenius_2019.pdf (Verlagsversion), 2MB
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 Urheber:
Albrecht, Franziska1, Autor           
Bisenius, Sandrine1, Autor           
Neumann, Jane1, 2, 3, Autor           
Whitwell, Jennifer4, Autor
Schroeter, Matthias L.1, 5, Autor           
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Department of Medical Engineering and Biotechnology, University of Applied Sciences, Jena, Germany, ou_persistent22              
3Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
4Department of Radiology, Mayo Clinic, Rochester, NY, USA, ou_persistent22              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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Schlagwörter: Anatomical likelihood estimation; Cerebellar pedunculi; Cerebral pedunculi; Imaging biomarker; Meta-analysis; Midbrain; Progressive supranuclear palsy; Seed-based D mapping
 Zusammenfassung: Objective

Progressive supranuclear palsy (PSP) is an atypical parkinsonian syndrome characterized by vertical gaze palsy and postural instability. Midbrain atrophy is suggested as a hallmark, but it has not been validated systematically in whole-brain imaging.
Methods

We conducted whole-brain meta-analyses identifying disease-related atrophy in structural MRI. Eighteen studies were identified (N = 315 PSP, 393 controls) and separated into gray or white matter analyses (15/12). All patients were diagnosed according to the National Institute of Neurological Disorders and Stroke and the Society for PSP (NINDS-SPSP criteria, Litvan et al. (1996a)), which are now considered as PSP-Richardson syndrome (Höglinger et al., 2017). With overlay analyses, we double-validated two meta-analytical algorithms: anatomical likelihood estimation and seed-based D mapping. Additionally, we conducted region-of-interest effect size meta-analyses on radiological biomarkers and subtraction analyses differentiating PSP from Parkinson's disease.
Results

Whole brain meta-analyses revealed consistent gray matter atrophy in bilateral thalamus, anterior insulae, midbrain, and left caudate nucleus. White matter alterations were consistently detected in bilateral superior/middle cerebellar pedunculi, cerebral pedunculi, and midbrain atrophy. Region-of-interest meta-analyses demonstrated that midbrain metrics generally perform very well in distinguishing PSP from other parkinsonian syndromes with strong effect sizes. Subtraction analyses identified the midbrain as differentiating between PSP and Parkinson's disease.
Conclusions

Our meta-analyses identify gray matter atrophy of the midbrain and white matter atrophy of the cerebral/cerebellar pedunculi and midbrain as characteristic for PSP. Results support the incorporation of structural MRI data, and particularly these structures, into the revised PSP diagnostic criteria.

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Sprache(n): eng - English
 Datum: 2019-02-132018-09-242019-02-152019-02-19
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.nicl.2019.101722
PMID: 30831462
Anderer: Epub ahead of print
 Art des Abschluß: -

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Projektinformation

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Projektname : -
Grant ID : PDF-IRG-1307
Förderprogramm : -
Förderorganisation : Parkinson's Disease Foundation
Projektname : -
Grant ID : MJFF-11362
Förderprogramm : -
Förderorganisation : Michael J Fox Foundation
Projektname : German Consortium for Frontotemporal Lobar Degeneration
Grant ID : 01GI1007A
Förderprogramm : -
Förderorganisation : German Federal Ministry of Education and Research (BMBF)
Projektname : -
Grant ID : SCHR 774/5-1
Förderprogramm : -
Förderorganisation : German Research Foundation (DFG)
Projektname : -
Grant ID : R01-NS89757
Förderprogramm : -
Förderorganisation : National Institutes of Health (NIH)
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity (IMPRS NeuroCom)
Projektname : -
Grant ID : 01EO1001
Förderprogramm : -
Förderorganisation : Federal Ministry of Education and Research Germany (BMBF)
Projektname : Obesity Mechanisms / SFB 1052
Grant ID : -
Förderprogramm : -
Förderorganisation : German Research Foundation (DFG)

Quelle 1

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Titel: NeuroImage: Clinical
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Elsevier
Seiten: - Band / Heft: 22 Artikelnummer: 101722 Start- / Endseite: - Identifikator: ISSN: 2213-1582
CoNE: https://pure.mpg.de/cone/journals/resource/2213-1582