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  Atrophy in midbrain & cerebral/cerebellar pedunculi is characteristic for progressive supranuclear palsy: A double-validation whole-brain meta-analysis

Albrecht, F., Bisenius, S., Neumann, J., Whitwell, J., & Schroeter, M. L. (2019). Atrophy in midbrain & cerebral/cerebellar pedunculi is characteristic for progressive supranuclear palsy: A double-validation whole-brain meta-analysis. NeuroImage: Clinical, 22: 101722. doi:10.1016/j.nicl.2019.101722.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0003-246D-B Version Permalink: https://hdl.handle.net/21.11116/0000-0004-5013-C
Genre: Journal Article

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 Creators:
Albrecht, Franziska1, Author           
Bisenius, Sandrine1, Author           
Neumann, Jane1, 2, 3, Author           
Whitwell, Jennifer4, Author
Schroeter, Matthias L.1, 5, Author           
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Department of Medical Engineering and Biotechnology, University of Applied Sciences, Jena, Germany, ou_persistent22              
3Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
4Department of Radiology, Mayo Clinic, Rochester, NY, USA, ou_persistent22              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Anatomical likelihood estimation; Cerebellar pedunculi; Cerebral pedunculi; Imaging biomarker; Meta-analysis; Midbrain; Progressive supranuclear palsy; Seed-based D mapping
 Abstract: Objective

Progressive supranuclear palsy (PSP) is an atypical parkinsonian syndrome characterized by vertical gaze palsy and postural instability. Midbrain atrophy is suggested as a hallmark, but it has not been validated systematically in whole-brain imaging.
Methods

We conducted whole-brain meta-analyses identifying disease-related atrophy in structural MRI. Eighteen studies were identified (N = 315 PSP, 393 controls) and separated into gray or white matter analyses (15/12). All patients were diagnosed according to the National Institute of Neurological Disorders and Stroke and the Society for PSP (NINDS-SPSP criteria, Litvan et al. (1996a)), which are now considered as PSP-Richardson syndrome (Höglinger et al., 2017). With overlay analyses, we double-validated two meta-analytical algorithms: anatomical likelihood estimation and seed-based D mapping. Additionally, we conducted region-of-interest effect size meta-analyses on radiological biomarkers and subtraction analyses differentiating PSP from Parkinson's disease.
Results

Whole brain meta-analyses revealed consistent gray matter atrophy in bilateral thalamus, anterior insulae, midbrain, and left caudate nucleus. White matter alterations were consistently detected in bilateral superior/middle cerebellar pedunculi, cerebral pedunculi, and midbrain atrophy. Region-of-interest meta-analyses demonstrated that midbrain metrics generally perform very well in distinguishing PSP from other parkinsonian syndromes with strong effect sizes. Subtraction analyses identified the midbrain as differentiating between PSP and Parkinson's disease.
Conclusions

Our meta-analyses identify gray matter atrophy of the midbrain and white matter atrophy of the cerebral/cerebellar pedunculi and midbrain as characteristic for PSP. Results support the incorporation of structural MRI data, and particularly these structures, into the revised PSP diagnostic criteria.

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Language(s): eng - English
 Dates: 2019-02-132018-09-242019-02-152019-02-19
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.nicl.2019.101722
PMID: 30831462
Other: Epub ahead of print
 Degree: -

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Project name : -
Grant ID : PDF-IRG-1307
Funding program : -
Funding organization : Parkinson's Disease Foundation
Project name : -
Grant ID : MJFF-11362
Funding program : -
Funding organization : Michael J Fox Foundation
Project name : German Consortium for Frontotemporal Lobar Degeneration
Grant ID : 01GI1007A
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : -
Grant ID : SCHR 774/5-1
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : R01-NS89757
Funding program : -
Funding organization : National Institutes of Health (NIH)
Project name : -
Grant ID : -
Funding program : -
Funding organization : International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity (IMPRS NeuroCom)
Project name : -
Grant ID : 01EO1001
Funding program : -
Funding organization : Federal Ministry of Education and Research Germany (BMBF)
Project name : Obesity Mechanisms / SFB 1052
Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)

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Title: NeuroImage: Clinical
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Elsevier
Pages: - Volume / Issue: 22 Sequence Number: 101722 Start / End Page: - Identifier: ISSN: 2213-1582
CoNE: https://pure.mpg.de/cone/journals/resource/2213-1582