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  In-host evolution of Staphylococcus epidermidis in a pacemaker-associated endocarditis resulting in increased antibiotic tolerance

Dengler Haunreiter, V., Boumasmoud, M., Häffner, N., Wipfli, D., Leimer, N., Rachmühl, C., et al. (2019). In-host evolution of Staphylococcus epidermidis in a pacemaker-associated endocarditis resulting in increased antibiotic tolerance. Nature Communications, 10: 1149. doi:10.1038/s41467-019-09053-9.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-27DC-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-27DD-9
Genre: Journal Article

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 Creators:
Dengler Haunreiter, Vanina1, Author
Boumasmoud, Mathilde1, Author
Häffner, Nicola1, Author
Wipfli, Dennis1, Author
Leimer, Nadja1, Author
Rachmühl, Carole1, Author
Kühnert, Denise1, Author              
Achermann, Yvonne1, Author
Zbinden, Reinhard1, Author
Benussi, Stefano1, Author
Vulin, Clement1, Author
Zinkernagel, Annelies S.1, Author
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1tide, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2591691              

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 Abstract: Treatment failure in biofilm-associated bacterial infections is an important healthcare issue. In vitro studies and mouse models suggest that bacteria enter a slow-growing/non-growing state that results in transient tolerance to antibiotics in the absence of a specific resistance mechanism. However, little clinical confirmation of antibiotic tolerant bacteria in patients exists. In this study we investigate a Staphylococcus epidermidis pacemaker-associated endocarditis, in a patient who developed a break-through bacteremia despite taking antibiotics to which the S. epidermidis isolate is fully susceptible in vitro. Characterization of the clinical S. epidermidis isolates reveals in-host evolution over the 16-week infection period, resulting in increased antibiotic tolerance of the entire population due to a prolonged lag time until growth resumption and a reduced growth rate. Furthermore, we observe adaptation towards an increased biofilm formation capacity and genetic diversification of the S. epidermidis isolates within the patient.

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Language(s): eng - English
 Dates: 2019-03-08
 Publication Status: Published online
 Pages: 14
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41467-019-09053-9
Other: shh1192
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 10 Sequence Number: 1149 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723