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  Neuroanatomical correlates of food addiction symptoms and body mass index in the general population

Beyer, F., Garcia-Garcia, I., Heinrich, M., Schroeter, M. L., Sacher, J., Luck, T., et al. (2019). Neuroanatomical correlates of food addiction symptoms and body mass index in the general population. Human Brain Mapping. doi:10.1002/hbm.24557.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-2C85-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-AB78-6
Genre: Journal Article

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 Creators:
Beyer, Frauke1, 2, Author              
Garcia-Garcia, Isabel1, 3, Author              
Heinrich, Matthias1, Author
Schroeter, Matthias L.1, 4, Author              
Sacher, Julia1, Author              
Luck, Tobias5, Author
Riedel-Heller, Steffi G.5, Author
Stumvoll, Michael6, Author
Villringer, Arno1, 4, Author              
Witte, A. Veronica1, 2, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
3Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada, ou_persistent22              
4Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
5Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
6Clinic for Endocrinology and Nephrology, University Hospital Leipzig, Germany, ou_persistent22              

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Free keywords: Body mass index; Cohort studies; Eating; Food addiction; Gray matter; Neuroimaging; Obesity
 Abstract: The food addiction model suggests neurobiological similarities between substance-related and addictive disorders and obesity. While structural brain differences have been consistently reported in these conditions, little is known about the neuroanatomical correlates of food addiction. We therefore aimed to determine whether symptoms of food addiction related to body mass index (BMI), personality, and brain structure in a large population-based sample. Participants of the LIFE-Adult study (n = 625; 20–59 years old, 45% women) answered the Yale Food Addiction Scale (YFAS) and further personality measures, underwent anthropometric assessments and high-resolution 3T-neuroimaging. A higher YFAS symptom score correlated with higher BMI, eating behavior traits, neuroticism, and stress. Higher BMI predicted significantly lower thickness of (pre)frontal, temporal and occipital cortex and increased volume of left nucleus accumbens. In a whole-brain analysis, YFAS symptom score was not associated with significant differences in cortical thickness or subcortical gray matter volumes. A hypothesis-driven Bayes factor analysis suggested a small, additional contribution of YFAS symptom score to lower right lateral orbitofrontal cortex thickness over the effect of BMI. Our study indicates that symptoms of food addiction do not account for the major part of the structural brain differences associated with BMI in the general population. Yet, symptoms of food addiction might explain additional variance in orbitofrontal cortex, a hub area of the reward network. Longitudinal studies implementing both anatomical and functional MRI could further disentangle the neural mechanisms of addictive eating behaviors.

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Language(s): eng - English
 Dates: 2019-01-152018-10-152019-02-142019-02-28
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/hbm.24557
PMID: 30816616
Other: Epub ahead of print
 Degree: -

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Project name : -
Grant ID : -
Funding program : European Social Fund
Funding organization : European Commission (EC)
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Funding program : European Regional Development Fund
Funding organization : European Commission (EC)
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Funding organization : Free State of Saxony
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Grant ID : 713‐241202
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Funding organization : LIFE–Leipzig Research Center for Civilization Diseases, University of Leipzig
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Grant ID : 14505/2470
Funding program : -
Funding organization : LIFE–Leipzig Research Center for Civilization Diseases, University of Leipzig
Project name : Obesity mechanisms / SFb 1052
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Funding program : -
Funding organization : German Research Foundation (DFG)
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Funding program : Branco Weiss Fellowship - Society in Science
Funding organization : ETH Zurich
Project name : -
Grant ID : 25034
Funding program : NARSAD Young Investigator Award
Funding organization : Brain and Behavior Research Foundation
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max Planck Society

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686