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  Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep

Stevner, A. B. A., Vidaurre, D., Cabral, J., Rapuano, K. M., Nielsen, S. F. V., Tagliazucchi, E., et al. (2019). Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep. Nature Communications, 10(1): 1035. doi:10.1038/s41467-019-08934-3.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0003-2C74-A Versions-Permalink: https://hdl.handle.net/21.11116/0000-0003-A47D-8
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 Urheber:
Stevner, Angus B. A.1, 2, 3, Autor
Vidaurre, Diego4, Autor
Cabral, Joana1, Autor
Rapuano, Kristina M.5, Autor
Nielsen, Soren Fons Vind6, Autor
Tagliazucchi, Enzo7, 8, 9, Autor
Laufs, Helmut8, 9, Autor
Vuust, Peter3, Autor
Deco, Gustavo10, 11, 12, 13, Autor           
Woolrich, M. W.4, Autor
Van Someren, Eus7, 14, Autor
Kringelbach, Morten L.1, 2, 3, 15, Autor
Affiliations:
1Department of Psychiatry, Warneford Hospital, University of Oxford, United Kingdom, ou_persistent22              
2Center of Functionally Integrative Neuroscience, Aarhus University, Denmark, ou_persistent22              
3Center for Music in the Brain, Aarhus University, Denmark, ou_persistent22              
4Wellcome Centre For Integrative Neuroimaging, Oxford Centre for Human Brain Activity (OHBA), University of Oxford, United Kingdom, ou_persistent22              
5Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA, ou_persistent22              
6Department of Applied Mathematics and Computer Science, Technical University of Denmark, Lyngby, Denmark, ou_persistent22              
7The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands, ou_persistent22              
8Department of Neurology, University Hospital of Schleswig-Holstein, Kiel, Germany, ou_persistent22              
9Brain Imaging Centre, Goethe University, Frankfurt, Germany, ou_persistent22              
10Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
11Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
12Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
13School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              
14Department of Integrative Neurophysiology, VU University Medical Center, Amsterdam, the Netherlands, ou_persistent22              
15ICVS - Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal, ou_persistent22              

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Schlagwörter: Electroencephalography – EEG; Functional magnetic resonance imaging; Non-REM sleep; Sleep
 Zusammenfassung: The modern understanding of sleep is based on the classification of sleep into stages defined by their electroencephalography (EEG) signatures, but the underlying brain dynamics remain unclear. Here we aimed to move significantly beyond the current state-of-the-art description of sleep, and in particular to characterise the spatiotemporal complexity of whole-brain networks and state transitions during sleep. In order to obtain the most unbiased estimate of how whole-brain network states evolve through the human sleep cycle, we used a Markovian data-driven analysis of continuous neuroimaging data from 57 healthy participants falling asleep during simultaneous functional magnetic resonance imaging (fMRI) and EEG. This Hidden Markov Model (HMM) facilitated discovery of the dynamic choreography between different whole-brain networks across the wake-non-REM sleep cycle. Notably, our results reveal key trajectories to switch within and between EEG-based sleep stages, while highlighting the heterogeneities of stage N1 sleep and wakefulness before and after sleep.

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Sprache(n): eng - English
 Datum: 2018-02-232019-02-112019-03-04
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1038/s41467-019-08934-3
PMID: 30833560
PMC: PMC6399232
 Art des Abschluß: -

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Projektinformation

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Projektname : Spanish National Project Complexity of Brain States
Grant ID : PSI2016-75688-P
Förderprogramm : -
Förderorganisation : Spanish Research Agency (AEI) and the European Regional Development Fund (ERDF)
Projektname : Human Brain Project Specific Grant Agreement 1 / HBP SGA1
Grant ID : 720270
Förderprogramm : Horizon 2020
Förderorganisation : European Commission (EC)
Projektname : The plasticity of parental caregiving: characterizing the brain mechanisms underlying normal and disrupted development of parenting / CAREGIVING
Grant ID : 615539
Förderprogramm : Funding Programme 7
Förderorganisation : European Commission (EC)
Projektname : Frontiers of technology for theranostics of cancer, metabolic and neurodegenerative diseases
Grant ID : NORTE-01-0145-FEDER-000023
Förderprogramm : Northern Portugal Regional Operational Programme (NORTE 2020)
Förderorganisation : CCDR-N
Projektname : -
Grant ID : DNRF117
Förderprogramm : -
Förderorganisation : Danish National Research Foundation

Quelle 1

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Titel: Nature Communications
  Kurztitel : Nat. Commun.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: London : Nature Publishing Group
Seiten: - Band / Heft: 10 (1) Artikelnummer: 1035 Start- / Endseite: - Identifikator: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723