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  Estimating average single-neuron visual receptive field sizes by fMRI

Keliris, G., Li, Q., Papanikolaou, A., Logothetis, N., & Smirnakis, S. (2019). Estimating average single-neuron visual receptive field sizes by fMRI. Proceedings of the National Academy of Sciences of the United States of America, 116(13), 6425-6434. doi:10.1073/pnas.1809612116.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-2F95-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-95B0-C
Genre: Journal Article

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Keliris, GA1, 2, Author              
Li, Q1, 2, Author              
Papanikolaou, A1, 2, Author              
Logothetis, NK1, 2, Author              
Smirnakis, SM, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: The noninvasive estimation of neuronal receptive field (RF) properties in vivo allows a detailed understanding of brain organization as well as its plasticity by longitudinal following of potential changes. Visual RFs measured invasively by electrophysiology in animal models have traditionally provided a great extent of our current knowledge about the visual brain and its disorders. Voxel-based estimates of population RF (pRF) by functional magnetic resonance imaging (fMRI) in humans revolutionized the field and have been used extensively in numerous studies. However, current methods cannot estimate single-neuron RF sizes as they reflect large populations of neurons with individual RF scatter. Here, we introduce an approach to estimate RF size using spatial frequency selectivity to checkerboard patterns. This method allowed us to obtain noninvasive, average single-neuron RF estimates over a large portion of human early visual cortex. These estimates were significantly smaller compared with prior pRF methods. Furthermore, fMRI and electrophysiology experiments in nonhuman primates demonstrated an exceptionally good match, validating the approach.

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 Dates: 2019-03
 Publication Status: Published in print
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 Identifiers: DOI: 10.1073/pnas.1809612116
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : PNAS
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 116 (13) Sequence Number: - Start / End Page: 6425 - 6434 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230