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  Occipital levels of GABA are related to severe headaches in migraine

Bigal, M., Hetherington, H., Pan, J., Tsang, A., Grosberg, B., Avdievich, N., et al. (2008). Occipital levels of GABA are related to severe headaches in migraine. Neurology, 70(22), 2078-2080. doi:10.1212/01.wnl.0000313376.07248.28.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-3094-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-3095-E
Genre: Journal Article

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https://n.neurology.org/content/70/22/2078 (Publisher version)
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 Creators:
Bigal, ME, Author
Hetherington, H, Author
Pan, J, Author
Tsang, A, Author
Grosberg, B, Author
Avdievich, NI1, Author              
Friedman , B, Author
Lipton, RB, Author
Affiliations:
1External Organizations, ou_persistent22              

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 Abstract: Although GABA has figured prominently in theories of migraine pathogenesis,1 brain levels of this transmitter have not been directly measured in migraineurs. This is of importance since, in migraine, neurophysiologic events account for brain hyperexcitability and subcortical disinhibition.2,3 Magnetic resonance spectroscopy (MRS) measures levels of metabolites in the human brain and may map regional changes in their levels.4 Accordingly, herein we used MRS to measure the levels of GABA in individuals with migraine with aura (MA), migraine without aura (MO), and in controls.

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 Dates: 2008-05
 Publication Status: Published in print
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Title: Neurology
Source Genre: Journal
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Pages: - Volume / Issue: 70 (22) Sequence Number: - Start / End Page: 2078 - 2080 Identifier: -