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  Fast proton spectroscopic imaging employing k-space weighting achieved by variable repetition times

Kühn, B., Dreher, W., Norris, D. G., & Leibfritz, D. (1996). Fast proton spectroscopic imaging employing k-space weighting achieved by variable repetition times. Magnetic Resonance in Medicine, 35(4), 457-464. doi:10.1002/mrm.1910350403.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-3CA1-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-4FFD-9
Genre: Journal Article

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 Creators:
Kühn, Bernd1, Author
Dreher, Wolfgang1, Author
Norris, David G.1, Author              
Leibfritz, Dieter1, Author
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1External Organizations, ou_persistent22              

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Free keywords: k-space weighting; proton spectroscopic imaging; rat brain
 Abstract: A k-space weighted spectroscopic imaging (SI) method is presented that allows a reduction in the total data acquisition time by up to 55% compared with standard SI. The k-space weighting is achieved by varying the repetition time, thus realizing an inherent apodization that corresponds to a circularly symmetric generalized Hamming filter. The flip angle is varied with the repetition time to enhance the signal-to-noise ratio. These techniques were employed using a short echo time of 10 ms. In vivo measurements on healthy rat brain at 4.7 T were conducted, obtaining two-dimensional spectroscopic imaging data from a 25 x 25 circularly reduced k-space area in as little as 5 min. The signal-to-noise ratio is sufficiently high to detect J-coupled resonances such as myo-inositol or glutamate/glutamine, demonstrating the ability to combine short acquisition times with comprehensive metabolic information. The T1 dependency of the apodization and the corresponding point spread function was evaluated by computer simulations. The achievable signal-to-noise ratio per unit time was compared with standard SI giving a parameter-dependent advantage of approximately 20% of the standard SI method.

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Language(s): eng - English
 Dates: 1995-11-171995-04-201995-11-242011-02-031996-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/mrm.1910350403
PMID: 8992194
 Degree: -

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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 35 (4) Sequence Number: - Start / End Page: 457 - 464 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149