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  Quantitative magnetic resonance imaging of the corpus callosum in childhood onset schizophrenia

Jacobsen, L. K., Giedd, J. N., Rajapakse, J., Hamburger, S. D., Vaituzis, A. C., Frazier, J. A., et al. (1997). Quantitative magnetic resonance imaging of the corpus callosum in childhood onset schizophrenia. Psychiatry Research: Neuroimaging, 68(2-3), 77-86. doi:10.1016/S0925-4927(96)03019-3.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-3A6C-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-3A6D-3
Genre: Journal Article

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 Creators:
Jacobsen, Leslie K.1, Author
Giedd, Jay N.1, Author
Rajapakse, Jagath1, Author              
Hamburger, Susan D.1, Author
Vaituzis, A. Catherine1, Author
Frazier, Jean A.1, Author
Lenane, Marge C.1, Author
Rapoport, Judith L.1, Author
Affiliations:
1External Organizations, ou_persistent22              

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Free keywords: Neurodevelopment; White matter; Gray matter; Midsagittal
 Abstract: Corpus callosum size has been found to be abnormal in adult schizophrenia, and other studies have implicated abnormal interhemispheric communication in this disorder. To assess continuity with brain abnormalities in the later onset disorder and to further localize brain maldevelopment, this structure was examined in a unique sample of childhood onset schizophrenics. Anatomic brain magnetic resonance imaging scans were acquired for 25 patients (mean age 13.9 +/- 2.1) who had onset of schizophrenia by age 12 (mean age at onset 9.9 +/- 1.9) and 55 normal children. The midsagittal area of the corpus callosum was divided into seven sections. With no adjustment for brain volume, no diagnostic differences were observed. After adjustment for the smaller cerebral volume of the schizophrenics, larger total, anterior and posterior corpus callosum areas emerged for the schizophrenics. These findings provide further evidence for continuity between childhood onset and later onset schizophrenia and support other studies showing white matter sparing in the context of decreased cortical volume.

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Language(s): eng - English
 Dates: 1996-07-251996-03-131996-10-011999-03-251997-02-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: PMID: 9104755
DOI: 10.1016/S0925-4927(96)03019-3
 Degree: -

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Title: Psychiatry Research: Neuroimaging
  Other : Psychiatry Res. Neuroimaging
Source Genre: Journal
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Publ. Info: Elsevier
Pages: - Volume / Issue: 68 (2-3) Sequence Number: - Start / End Page: 77 - 86 Identifier: ISSN: 0925-4927
CoNE: https://pure.mpg.de/cone/journals/resource/954925566740