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  "Willed action": A functional MRI study of the human prefrontal cortex during a sensorimotor task

Hyder, F., Phelps, E. A., Wiggins, C. J., LaBar, K. S., Blamire, A. M., & Shulman, R. G. (1997). "Willed action": A functional MRI study of the human prefrontal cortex during a sensorimotor task. Proceedings of the National Academy of Sciences of the United States of America, 94(13), 6989-6994. doi:10.1073/pnas.94.13.6989.

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Hyder , Fahmeed1, Author
Phelps, Elizabeth A.1, Author
Wiggins, Christopher J.2, Author           
LaBar, Kevin S.1, Author
Blamire, Andrew M.1, Author
Shulman, Robert G.1, Author
1External Organizations, ou_persistent22              
2MPI of Cognitive Neuroscience (Leipzig, -2003), The Prior Institutes, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634574              


Free keywords: positron emission tomography; human brain mapping; dorsolateral prefrontal cortex; verbal fluency; Brodmann areas 6, 8, 9, 24, 32, 45, and 46
 Abstract: Functional MRI (fMRI) was used to examine human brain activity within the dorsolateral prefrontal cortex during a sensorimotor task that had been proposed to require selection between several responses, a cognitive concept termed "willed action" in a positron emission tomography (PET) study by Frith et al. [Frith, C. D., Friston, K., Liddle, P. F. & Frackowiak, R. S. J. (1991) Proc. R. Soc. London Ser. B 244, 241-246]. We repeated their sensorimotor task, in which the subject chooses to move either of two fingers after a stimulus, by fMRI experiments in a 2.1-T imaging spectrometer. Echo-planar images were acquired from four coronal slices in the prefrontal cortex from nine healthy subjects. Slices were 5 mm thick, centers separated by 7 mm, with nominal in-plane spatial resolution of 9.6 x 5.0 mm2 for mean data. Our mean results are in agreement with the PET results in that we saw similar bilateral activations. The present results are compared with our previously published fMRI study of a verbal fluency task, which had also been proposed by Frith et al. to elicit a "willed action" response. We find a clear separation of activation foci in the left dorsolateral prefrontal cortex for the sensorimotor (Brodmann area 46) and verbal fluency (Brodmann area 45) tasks. Hence, assigning a particular activated region to "willed action" is not supported by the fMRI data when examined closely because identical regions are not activated with different modalities. Similar modality linked activations can be observed in the original PET study but the greater resolution of the fMRI data makes the modality linkages more definite.


Language(s): eng - English
 Dates: 1997-04-141997-06-241997-06-24
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1073/pnas.94.13.6989
PMID: 9192679
PMC: PMC21272
 Degree: -



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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : PNAS
Source Genre: Journal
Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 94 (13) Sequence Number: - Start / End Page: 6989 - 6994 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230