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  Global long terminal repeat activation participates in establishing the unique gene expression programme of classical Hodgkin lymphoma

Edginton-White, B., Cauchy, P., Assi, S. A., Hartmann, S., Mathas, S., Cockerill, P. N., et al. (2018). Global long terminal repeat activation participates in establishing the unique gene expression programme of classical Hodgkin lymphoma. Leukemia: the Journal of Normal and Malignant Hemopoiese; Official Journal of the Leukemia Research Fund U.K. doi:10.1038/s41375-018-0311-x.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-6E74-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-E126-3
Genre: Journal Article

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 Creators:
Edginton-White, Benjamin1, Author
Cauchy, Pierre2, Author              
Assi, Salam A.1, Author
Hartmann, Sylvia1, Author
Mathas, Stephan1, Author
Cockerill, Peter N.1, Author
Bonifer, Constanze1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              

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 Abstract: Long terminal repeat (LTR) elements are wide-spread in the human genome and have the potential to act as promoters and enhancers. Their expression is therefore under tight epigenetic control. We previously reported in classical Hodgkin Lymphoma (cHL) that a member of the THE1B class of LTR elements acted as a promoter for the proto-oncogene and growth factor receptor gene CSF1R and that expression of this gene is required for cHL tumour survival. However, to which extent and how such elements participate in globally shaping the unique cHL gene expression programme is unknown. To address this question we mapped the genome-wide activation of THE1-LTRs in cHL cells using a targeted next generation sequencing approach (RACE-Seq). Integration of these data with global gene expression data from cHL and control B cell lines showed a unique pattern of LTR activation impacting on gene expression, including genes associated with the cHL phenotype. We also show that global LTR activation is induced by strong inflammatory stimuli. Together these results demonstrate that LTR activation provides an additional layer of gene deregulation in classical Hodgkin lymphoma and highlight the potential impact of genome-wide LTR activation in other inflammatory diseases.

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Language(s): eng - English
 Dates: 2018-12-13
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41375-018-0311-x
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Title: Leukemia : the Journal of Normal and Malignant Hemopoiese ; Official Journal of the Leukemia Research Fund U.K.
  Alternative Title : Leukemia (Online-Ausg.)
Source Genre: Journal
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Publ. Info: Basingstoke : Nature Publ. Group
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: n.a.: /journals/resource/954925554401