English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Specificity of resistance and geographic patterns of virulence in a vertebrate host-parasite system

Piecyk, A., Roth, O., Piecyk, A., & Kalbe, M. (2019). Specificity of resistance and geographic patterns of virulence in a vertebrate host-parasite system. BMC Evolutionary Biology, 19(1), 1-14. doi:10.1186/s12862-019-1406-3.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0003-39D5-D Version Permalink: http://hdl.handle.net/21.11116/0000-0004-4B04-4
Genre: Journal Article

Files

show Files
hide Files
:
Piecyk_et_al_2019.pdf (Publisher version), 2MB
Name:
Piecyk_et_al_2019.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
Correction_Piecyk_et_al_2019.pdf (Publisher version), 2MB
Name:
Correction_Piecyk_et_al_2019.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
Description:
-

Creators

show
hide
 Creators:
Piecyk, Agnes1, 2, Author              
Roth, Olivia, Author
Piecyk, Agnes2, Author              
Kalbe, Martin2, Author              
Affiliations:
1IMPRS for Evolutionary Biology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445639              
2Research Group Parasitology, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445643              

Content

show
hide
Free keywords: -
 Abstract: Background Host genotype - parasite genotype co-evolutionary dynamics are influenced by local biotic and abiotic environmental conditions. This results in spatially heterogeneous selection among host populations. How such heterogeneous selection influences host resistance, parasite infectivity and virulence remains largely unknown. We hypothesized that different co-evolutionary trajectories of a vertebrate host-parasite association result in specific virulence patterns when assessed on a large geographic scale. We used two reference host populations of three-spined sticklebacks and nine strains of their specific cestode parasite Schistocephalus solidus from across the Northern Hemisphere for controlled infection experiments. Host and parasite effects on infection phenotypes including host immune gene expression were determined. Results S. solidus strains grew generally larger in hosts coming from a population with high parasite diversity and low S. solidus prevalence (DE hosts). Hosts from a population with low parasite diversity and high S. solidus prevalence (NO hosts) were better able to control the parasite’s growth, regardless of the origin of the parasite. Host condition and immunological parameters converged upon infection and parasite growth showed the same geographic pattern in both host types. Conclusion Our results suggest that NO sticklebacks evolved resistance against a variety of S. solidus strains, whereas DE sticklebacks are less resistant against S. solidus. Our data provide evidence that differences in parasite prevalence can cause immunological heterogeneity and that parasite size, a proxy for virulence and resistance, is, on a geographic scale, determined by main effects of the host and the parasite and less by an interaction of both genotypes.

Details

show
hide
Language(s): eng - English
 Dates: 2018-10-242019-02-282019-03-192019
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1186/s12862-019-1406-3
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : ERC Starting Grant
Grant ID : MALEPREG
Funding program : German Science Foundation DFG (Priority Program 1399)
Funding organization : -
Project name : German Research Foundation
Grant ID : 349393951
Funding program : -
Funding organization : -
Project name : German Research Foundation
Grant ID : 237263721
Funding program : -
Funding organization : -
Project name : German Research Foundation
Grant ID : 274695381
Funding program : -
Funding organization : -

Source 1

show
hide
Title: BMC Evolutionary Biology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: BioMed Central
Pages: 80 Volume / Issue: 19 (1) Sequence Number: - Start / End Page: 1 - 14 Identifier: ISSN: 1471-2148
CoNE: https://pure.mpg.de/cone/journals/resource/111000136905006