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  Role for Chromatin Remodeling Factor Chd1 in Learning and Memory

Schoberleitner, I., Mutti, A., Sah, A., Wille, A., Gimeno-Valiente, F., Piatti, P., et al. (2019). Role for Chromatin Remodeling Factor Chd1 in Learning and Memory. Frontiers in Molecular Neuroscience, 12: 3. doi:10.3389/fnmol.2019.00003.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-4017-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-401B-7
Genre: Journal Article

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fnmol-12-00003.pdf (Publisher version), 3MB
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© 2019 Schoberleitner, Mutti, Sah, Wille, Gimeno-Valiente, Piatti, Kharitonova, Torres, López-Rodas, Liu, Singewald, Schwarzer and Lusser.
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Data_Sheet_1_Role for Chromatin Remodeling Factor Chd1 in Learning and Memory.pdf (Supplementary material), 3MB
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 Creators:
Schoberleitner, Ines1, Author
Mutti, Anna1, Author
Sah, Anupam1, Author
Wille, Alexandra1, Author
Gimeno-Valiente, Francisco1, Author
Piatti, Paolo1, Author
Kharitonova, Maria1, Author
Torres, Luis1, Author
Lopez-Rodas, Gerardo1, Author
Liu, Jeffrey J.2, Author              
Singewald, Nicolas1, Author
Schwarzer, Christoph1, Author
Lusser, Alexandra1, Author
Affiliations:
1external, ou_persistent22              
2Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

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Free keywords: TRANSCRIPTION ELONGATION-FACTORS; SYNAPTIC PLASTICITY; EPIGENETIC REGULATION; PROSTATE-CANCER; SUBUNIT BAF53B; GROWTH; GENE; EXPRESSION; INTERACTS; PROTEINNeurosciences & Neurology; chromatin; learning; memory; cognition; epigenetics; immediate early genes; hippocampus; gene expression;
 Abstract: Precise temporal and spatial regulation of gene expression in the brain is a prerequisite for cognitive processes such as learning and memory. Epigenetic mechanisms that modulate the chromatin structure have emerged as important regulators in this context. While posttranslational modification of histones or the modification of DNA bases have been examined in detail in many studies, the role of ATP-dependent chromatin remodeling factors (ChRFs) in learning- and memory-associated gene regulation has largely remained obscure. Here we present data that implicate the highly conserved chromatin assembly and remodeling factor Chd1 in memory formation and the control of immediate early gene (IEG) response in the hippocampus. We used various paradigms to assess short-and long-term memory in mice bearing a mutated Chd1 gene that gives rise to an N-terminally truncated protein. Our data demonstrate that the Chd1 mutation negatively affects long-term object recognition and short- and long-term spatial memory. We found that Chd1 regulates hippocampal expression of the IEG early growth response 1 (Egr1) and activity-regulated cytoskeleton-associated (Arc) but not cFos and brain derived neurotrophic factor (Bdnf), because the Chd1-mutation led to dysregulation of Egr1 and Arc expression in naive mice and in mice analyzed at different stages of object location memory (OLM) testing. Of note, Chd1 likely regulates Egr1 in a direct manner, because chromatin immunoprecipitation (ChIP) assays revealed enrichment of Chd1 upon stimulation at the Egr1 genomic locus in the hippocampus and in cultured cells. Together these data support a role for Chd1 as a critical regulator of molecular mechanisms governing memory-related processes, and they show that this function involves the N-terminal serine-rich region of the protein.

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Language(s): eng - English
 Dates: 2019
 Publication Status: Published online
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: ISI: 000456576900001
DOI: 10.3389/fnmol.2019.00003
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Title: Frontiers in Molecular Neuroscience
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 12 Sequence Number: 3 Start / End Page: - Identifier: ISSN: 1662-5099
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5099