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  Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and beta-catenin signaling

Volckaert, T., Yuan, T., Yuan, J., Boateng, E., Hopkins, S., Zhang, J.-S., et al. (2019). Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and beta-catenin signaling. Development, 146(2): UNSP dev166454. doi:10.1242/dev.166454.

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 Creators:
Volckaert, Thomas1, Author
Yuan, Tingting1, Author
Yuan, Jie1, Author
Boateng, Eistine1, Author
Hopkins, Seantel1, Author
Zhang, Jin-San1, Author
Thannickal, Victor J.1, Author
Fässler, Reinhard2, Author           
De Langhe, Stijn P.1, Author
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1external, ou_persistent22              
2Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              

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Free keywords: INTEGRIN-LINKED KINASE; BRANCHING MORPHOGENESIS; MESENCHYMAL CROSSTALK; CELL PROGENITORS; GROWTH; DIFFERENTIATION; PATHWAY; WNT; EXPRESSION; YAP/TAZDevelopmental Biology; Lung; Hippo; Yap; Fgfr2; Ilk; Fgf10; Integrin; beta-Catenin; Differentiation; Progenitor;
 Abstract: Organ growth and tissue homeostasis rely on the proliferation and differentiation of progenitor cell populations. In the developing lung, localized Fgf10 expression maintains distal Sox9-expressing epithelial progenitors and promotes basal cell differentiation in the cartilaginous airways. Mesenchymal Fgf10 expression is induced by Wnt signaling but inhibited by Shh signaling, and epithelial Fgf10 signaling activates beta-catenin signaling. The Hippo pathway is a well-conserved signaling cascade that regulates organ size and stem/progenitor cell behavior. Here, we show that Hippo signaling promotes lineage commitment of lung epithelial progenitors by curbing Fgf10 and beta-catenin signaling. Our findings show that both inactivation of the Hippo pathway (nuclear Yap) or ablation of Yap result in increased beta-catenin and Fgf10 signaling, suggesting a cytoplasmic role for Yap in epithelial lineage commitment. We further demonstrate redundant and non-redundant functions for the two nuclear effectors of the Hippo pathway, Yap and Taz, during lung development.

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Language(s): eng - English
 Dates: 2019
 Publication Status: Published online
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000457418100003
DOI: 10.1242/dev.166454
 Degree: -

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Title: Development
  Other : Development
Source Genre: Journal
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Publ. Info: Cambridge, Cambridgeshire : Company of Biologists
Pages: - Volume / Issue: 146 (2) Sequence Number: UNSP dev166454 Start / End Page: - Identifier: ISSN: 0950-1991
CoNE: https://pure.mpg.de/cone/journals/resource/954927546241