Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

 
 
DownloadE-Mail
  Mechanisms Preserving Insulin Action during High Dietary Fat Intake

Lundsgaard, A.-M., Holm, J. B., Sjoberg, K. A., Bojsen-Moller, K. N., Myrmel, L. S., Fjaere, E., et al. (2019). Mechanisms Preserving Insulin Action during High Dietary Fat Intake. Cell Metabolism, 29(1), 50-63.e4. doi:10.1016/j.cmet.2018.08.022.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Lundsgaard, Anne-Marie1, Autor
Holm, Jacob B.1, Autor
Sjoberg, Kim A.1, Autor
Bojsen-Moller, Kirstine N.1, Autor
Myrmel, Lene S.1, Autor
Fjaere, Even1, Autor
Jensen, Benjamin A. H.1, Autor
Nicolaisen, Trine S.1, Autor
Hingst, Janne R.1, Autor
Hansen, Sine L.1, Autor
Doll, Sophia2, Autor           
Geyer, Philipp E.2, Autor           
Deshmukh, Atul S.1, Autor
Holst, Jens J.1, Autor
Madsen, Lise1, Autor
Kristiansen, Karsten1, Autor
Wojtaszewski, Jorgen F. P.1, Autor
Richter, Erik A.1, Autor
Kiens, Bente1, Autor
Affiliations:
1external, ou_persistent22              
2Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

Inhalt

einblenden:
ausblenden:
Schlagwörter: LIPOPROTEIN-LIPASE ACTIVITY; ACETYL-COA CARBOXYLASE-1; DE-NOVO LIPOGENESIS; SKELETAL-MUSCLE; LIQUID-CHROMATOGRAPHY; GLUCOSE-METABOLISM; HIGH-CARBOHYDRATE; KETONE-BODIES; LIVER; ACIDSCell Biology; Endocrinology & Metabolism;
 Zusammenfassung: Prolonged intervention studies investigating molecular metabolism are necessary for a deeper understanding of dietary effects on health. Here we provide mechanistic information about metabolic adaptation to fat-rich diets. Healthy, slightly overweight men ingested saturated or polyunsaturated fat-rich diets for 6 weeks during weight maintenance. Hyperinsulinemic clamps combined with leg balance technique revealed unchanged peripheral insulin sensitivity, independent of fatty acid type. Both diets increased fat oxidation potential in muscle. Hepatic insulin clearance increased, while glucose production, de novo lipogenesis, and plasma triacylglycerol decreased. High fat intake changed the plasma proteome in the immune-supporting direction and the gut microbiome displayed changes at taxonomical and functional level with polyunsaturated fatty acid (PUFA). In mice, eucaloric feeding of human PUFA and saturated fatty acid diets lowered hepatic triacylglycerol content compared with low-fat-fed control mice, and induced adaptations in the liver supportive of decreased gluconeogenesis and lipogenesis. Intake of fat-rich diets thus induces extensive metabolic adaptations enabling disposition of dietary fat without metabolic complications.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2019
 Publikationsstatus: Erschienen
 Seiten: 18
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: 000455090100010
DOI: 10.1016/j.cmet.2018.08.022
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Cell Metabolism
  Andere : Cell Metabolism
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Cambridge, MA : Cell Press
Seiten: - Band / Heft: 29 (1) Artikelnummer: - Start- / Endseite: 50 - 63.e4 Identifikator: ISSN: 1550-4131
CoNE: https://pure.mpg.de/cone/journals/resource/111088195284928