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  Mechanisms Preserving Insulin Action during High Dietary Fat Intake

Lundsgaard, A.-M., Holm, J. B., Sjoberg, K. A., Bojsen-Moller, K. N., Myrmel, L. S., Fjaere, E., et al. (2019). Mechanisms Preserving Insulin Action during High Dietary Fat Intake. Cell Metabolism, 29(1), 50-63.e4. doi:10.1016/j.cmet.2018.08.022.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-4045-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-4046-6
Genre: Journal Article

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 Creators:
Lundsgaard, Anne-Marie1, Author
Holm, Jacob B.1, Author
Sjoberg, Kim A.1, Author
Bojsen-Moller, Kirstine N.1, Author
Myrmel, Lene S.1, Author
Fjaere, Even1, Author
Jensen, Benjamin A. H.1, Author
Nicolaisen, Trine S.1, Author
Hingst, Janne R.1, Author
Hansen, Sine L.1, Author
Doll, Sophia2, Author              
Geyer, Philipp E.2, Author              
Deshmukh, Atul S.1, Author
Holst, Jens J.1, Author
Madsen, Lise1, Author
Kristiansen, Karsten1, Author
Wojtaszewski, Jorgen F. P.1, Author
Richter, Erik A.1, Author
Kiens, Bente1, Author
Affiliations:
1external, ou_persistent22              
2Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

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Free keywords: LIPOPROTEIN-LIPASE ACTIVITY; ACETYL-COA CARBOXYLASE-1; DE-NOVO LIPOGENESIS; SKELETAL-MUSCLE; LIQUID-CHROMATOGRAPHY; GLUCOSE-METABOLISM; HIGH-CARBOHYDRATE; KETONE-BODIES; LIVER; ACIDSCell Biology; Endocrinology & Metabolism;
 Abstract: Prolonged intervention studies investigating molecular metabolism are necessary for a deeper understanding of dietary effects on health. Here we provide mechanistic information about metabolic adaptation to fat-rich diets. Healthy, slightly overweight men ingested saturated or polyunsaturated fat-rich diets for 6 weeks during weight maintenance. Hyperinsulinemic clamps combined with leg balance technique revealed unchanged peripheral insulin sensitivity, independent of fatty acid type. Both diets increased fat oxidation potential in muscle. Hepatic insulin clearance increased, while glucose production, de novo lipogenesis, and plasma triacylglycerol decreased. High fat intake changed the plasma proteome in the immune-supporting direction and the gut microbiome displayed changes at taxonomical and functional level with polyunsaturated fatty acid (PUFA). In mice, eucaloric feeding of human PUFA and saturated fatty acid diets lowered hepatic triacylglycerol content compared with low-fat-fed control mice, and induced adaptations in the liver supportive of decreased gluconeogenesis and lipogenesis. Intake of fat-rich diets thus induces extensive metabolic adaptations enabling disposition of dietary fat without metabolic complications.

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Language(s): eng - English
 Dates: 2019
 Publication Status: Published in print
 Pages: 18
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Degree: -

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Title: Cell Metabolism
  Other : Cell Metabolism
Source Genre: Journal
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Publ. Info: Cambridge, MA : Cell Press
Pages: - Volume / Issue: 29 (1) Sequence Number: - Start / End Page: 50 - 63.e4 Identifier: ISSN: 1550-4131
CoNE: https://pure.mpg.de/cone/journals/resource/111088195284928