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Free keywords:
THYROID-CANCER CELLS; DIFFERENTIAL GENE-EXPRESSION; ARABIDOPSIS-THALIANA
CALLUS; ALTERED GRAVITY CONDITIONS; SATIVA L. SEEDLINGS; SPHEROID
FORMATION; ENDOTHELIAL-CELLS; SIMULATED MICROGRAVITY; 3-DIMENSIONAL
GROWTH; HUMAN CHONDROCYTESBiochemistry & Molecular Biology; Proteome; mass spectrometry; plants; human cells; tissue engineering;
cancer;
Abstract:
Introduction: Microgravity (mu g) is an extreme stressor for plants, animals, and humans and influences biological systems. Humans in space experience various health problems during and after a long-term stay in orbit. Various studies have demonstrated structural alterations and molecular biological changes within the cellular milieu of plants, bacteria, microorganisms, animals, and cells. These data were obtained by proteomics investigations applied in gravitational biology to elucidate changes in the proteome occurring when cells or organisms were exposed to real mu g (r-mu g) and simulated mu g (s-mu g). Areas covered: In this review, we summarize the current knowledge about the impact of mu g on the proteome in plants, animals, and human cells. The literature suggests that mu g impacts the proteome and thus various biological processes such as angiogenesis, apoptosis, cell adhesion, cytoskeleton, extracellular matrix proteins, migration, proliferation, stress response, and signal transduction. The changes in cellular function depend on the respective cell type. Expert commentary: This data is important for the topics of gravitational biology, tissue engineering, cancer research, and translational regenerative medicine. Moreover, it may provide new ideas for countermeasures to protect the health of future space travelers.
