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  Integrin activation by talin, kindlin and mechanical forces

Sun, Z., Costell, M., & Fässler, R. (2019). Integrin activation by talin, kindlin and mechanical forces. Nature Cell Biology, 21(1), 25-31. doi:10.1038/s41556-018-0234-9.

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 Creators:
Sun, Zhiqi1, Author              
Costell, Mercedes2, Author
Fässler, Reinhard1, Author              
Affiliations:
1Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              
2external, ou_persistent22              

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Free keywords: NANOSCALE ARCHITECTURE; STRUCTURAL BASIS; ADHESION; SHARPIN; CONFORMATION; TRANSDUCTION; INFLAMMATION; RECOGNITION; EXTENSION; MEMBRANECell Biology;
 Abstract: Integrins are the major family of adhesion molecules that mediate cell adhesion to the extracellular matrix. They are essential for embryonic development and influence numerous diseases, including inflammation, cancer cell invasion and metastasis. In this Perspective, we discuss the current understanding of how talin, kindlin and mechanical forces regulate integrin affinity and avidity, and how integrin inactivators function in this framework.

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Language(s): eng - English
 Dates: 2019
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000454708400005
DOI: 10.1038/s41556-018-0234-9
 Degree: -

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Title: Nature Cell Biology
  Other : 'Nat. Cell Biol.'
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Macmillan Magazines Ltd.
Pages: - Volume / Issue: 21 (1) Sequence Number: - Start / End Page: 25 - 31 Identifier: ISSN: 1465-7392
CoNE: https://pure.mpg.de/cone/journals/resource/954925625310