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  Gadobutrol enhances T1-weighted MRI of nerve cells.

Watanabe, T., & Frahm, J. (2019). Gadobutrol enhances T1-weighted MRI of nerve cells. Toxicology Letters, 308, 17-23. doi:10.1016/j.toxlet.2019.03.005.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-40AF-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-70C7-E
Genre: Journal Article

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3036309.pdf (Preprint), 674KB
 
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 Creators:
Watanabe, T.1, Author              
Frahm, J.1, Author              
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

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Free keywords: dorsal motor nucleus of vagus; gadolinium-based contrast agent; locus coeruleus; macrocyclic; magnetization transfer; nucleus ambiguus
 Abstract: Three-dimensional T1-weighted MRI of mouse brain in vivo (9.4 T, 80 µm isotropic resolution) identified assemblies of nerve cell bodies in the habenula, hippocampal formation, locus coeruleus, dorsal motor nucleus of vagus, and nucleus ambiguus as high signal intensities, while suppressing the signals of white matter by magnetization transfer and extracellular water protons by saturation. These observations indicate the presence of intracellular water protons with T1 values shortened by paramagnetic ions as the source of the bright signal. One day after an intraventricular injection of gadobutrol, a macrocyclic gadolinium-based contrast agent, T1-weighted MRI signal intensities of the nerve cell assemblies in the habenula, hippocampal formation, and locus coeruleus increased significantly. With simultaneous saturation of long-T1 protons of extracellular water, this finding indicates a T1-shortening of the intracellular water protons as a result of their interaction with gadolinium ions.

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Language(s): eng - English
 Dates: 2019-03-192019-06-15
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.toxlet.2019.03.005
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Title: Toxicology Letters
Source Genre: Journal
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Pages: - Volume / Issue: 308 Sequence Number: - Start / End Page: 17 - 23 Identifier: -