English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  CACNA1C risk variant affects microstructural connectivity of the amygdala

Koch, K., Stegmaier, S., Schwarz, A., Erb, M., Thomas, M., Scheffler, K., et al. (2019). CACNA1C risk variant affects microstructural connectivity of the amygdala. NeuroImage: Clinical, 22: 101774, pp. 1-8. doi:10.1016/j.nicl.2019.101774.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0003-422E-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-422F-F
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Koch, K, Author
Stegmaier, S, Author
Schwarz, A, Author
Erb, M, Author              
Thomas, M, Author
Scheffler, K1, 2, Author              
Wildgruber, D, Author
Nieratschker, V, Author
Ethofer, T, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

Content

show
hide
Free keywords: -
 Abstract: Deficits in perception of emotional prosody have been described in patients with affective disorders at behavioral and neural level. In the current study, we use an imaging genetics approach to examine the impact of CACNA1C, one of the most promising genetic risk factors for psychiatric disorders, on prosody processing on a behavioral, functional and microstructural level. Using functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) we examined key areas involved in prosody processing, i.e. the amygdala and voice areas, in a healthy population. We found stronger activation to emotional than neutral prosody in the voice areas and the amygdala, but CACNA1C rs1006737 genotype had no influence on fMRI activity. However, significant microstructural differences (i.e. mean diffusivity) between CACNA1C rs1006737 risk allele carriers and non carriers were found in the amygdala, but not the voice areas. These modifications in brain architecture associated with CACNA1C might reflect a neurobiological marker predisposing to affective disorders and concomitant alterations in emotion perception.

Details

show
hide
Language(s):
 Dates: 2019-03
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.nicl.2019.101774
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: NeuroImage: Clinical
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Elsevier
Pages: - Volume / Issue: 22 Sequence Number: 101774 Start / End Page: 1 - 8 Identifier: ISSN: 2213-1582
CoNE: https://pure.mpg.de/cone/journals/resource/2213-1582