Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  CACNA1C risk variant affects microstructural connectivity of the amygdala

Koch, K., Stegmaier, S., Schwarz, A., Erb, M., Thomas, M., Scheffler, K., et al. (2019). CACNA1C risk variant affects microstructural connectivity of the amygdala. NeuroImage: Clinical, 22: 101774. doi:10.1016/j.nicl.2019.101774.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:
ausblenden:
Beschreibung:
-
OA-Status:
Keine Angabe

Urheber

einblenden:
ausblenden:
 Urheber:
Koch, K, Autor
Stegmaier, S, Autor
Schwarz, A, Autor
Erb, M, Autor           
Thomas, M, Autor
Scheffler, K1, Autor           
Wildgruber, D, Autor
Nieratschker, V, Autor
Ethofer, T, Autor                 
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Deficits in perception of emotional prosody have been described in patients with affective disorders at behavioral and neural level. In the current study, we use an imaging genetics approach to examine the impact of CACNA1C, one of the most promising genetic risk factors for psychiatric disorders, on prosody processing on a behavioral, functional and microstructural level. Using functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) we examined key areas involved in prosody processing, i.e. the amygdala and voice areas, in a healthy population. We found stronger activation to emotional than neutral prosody in the voice areas and the amygdala, but CACNA1C rs1006737 genotype had no influence on fMRI activity. However, significant microstructural differences (i.e. mean diffusivity) between CACNA1C rs1006737 risk allele carriers and non carriers were found in the amygdala, but not the voice areas. These modifications in brain architecture associated with CACNA1C might reflect a neurobiological marker predisposing to affective disorders and concomitant alterations in emotion perception.

Details

einblenden:
ausblenden:
Sprache(n):
 Datum: 2019-03
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1016/j.nicl.2019.101774
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: NeuroImage: Clinical
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Elsevier
Seiten: 8 Band / Heft: 22 Artikelnummer: 101774 Start- / Endseite: - Identifikator: ISSN: 2213-1582
CoNE: https://pure.mpg.de/cone/journals/resource/2213-1582