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  Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder

Figueroa, C. A., Cabral, J., Mocking, R. J. T., Rapuano, K. M., van Hartevelt, T. J., Deco, G., et al. (2019). Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder. Human Brain Mapping, 40(9), 2771-2786. doi:10.1002/hbm.24559.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-4286-B Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B0B5-9
Genre: Journal Article

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 Creators:
Figueroa, Caroline A. 1, 2, 3, Author
Cabral , Joana 4, 5, 6, Author
Mocking, Roel J. T. 1, 2, Author
Rapuano, Kristina M.7, Author
van Hartevelt, Tim J. 4, Author
Deco, Gustavo8, 9, 10, 11, Author              
Expert, Paul 12, 13, Author
Schene , Aart H. 1, 14, 15, Author
Kringelbach , Morten L. 4, 5, 6, Author
Ruhé, Henricus G. 1, 4, 14, 15, Author
Affiliations:
1Faculty of Medicine, University of Amsterdam, the Netherlands, ou_persistent22              
2Spinoza Centre for Neuroimaging, University of Amsterdam, the Netherlands, ou_persistent22              
3School of Social Welfare, University of California, Berkeley, CA, USA, ou_persistent22              
4Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
5ICVS - Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal, ou_persistent22              
6Center for Music in the Brain, Aarhus University, Denmark, ou_persistent22              
7Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA, ou_persistent22              
8Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
9Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
10Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
11School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              
12Centre for Mathematics of Precision Healthcare, Imperial College London, United Kingdom, ou_persistent22              
13Department of Mathematics, Imperial College London, United Kingdom, ou_persistent22              
14Department of Psychiatry, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
15Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands, ou_persistent22              

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Free keywords: Cognitive control; Dynamic FC; Functional networks; Major depressive disorder; Resting-state fMRI
 Abstract: Neurobiological models to explain vulnerability of major depressive disorder (MDD) are scarce and previous functional magnetic resonance imaging studies mostly examined “static” functional connectivity (FC). Knowing that FC constantly evolves over time, it becomes important to assess how FC dynamically differs in remitted‐MDD patients vulnerable for new depressive episodes. Using a recently developed method to examine dynamic FC, we characterized re‐emerging FC states during rest in 51 antidepressant‐free MDD patients at high risk of recurrence (≥2 previous episodes), and 35 healthy controls. We examined differences in occurrence, duration, and switching profiles of FC states after neutral and sad mood induction. Remitted MDD patients showed a decreased probability of an FC state (p < 0.005) consisting of an extensive network connecting frontal areas—important for cognitive control—with default mode network, striatum, and salience areas, involved in emotional and self‐referential processing. Even when this FC state was observed in patients, it lasted shorter (p < 0.005) and was less likely to switch to a smaller prefrontal–striatum network (p < 0.005). Differences between patients and controls decreased after sad mood induction. Further, the duration of this FC state increased in remitted patients after sad mood induction but not in controls (p < 0.05). Our findings suggest reduced ability of remitted‐MDD patients, in neutral mood, to access a clinically relevant control network involved in the interplay between externally and internally oriented attention. When recovering from sad mood, remitted recurrent MDD appears to employ a compensatory mechanism to access this FC state. This study provides a novel neurobiological profile of MDD vulnerability.

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Language(s): eng - English
 Dates: 2019-01-302018-07-082019-02-212019-03-122019-06-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/hbm.24559
PMID: 30864248
Other: Epub ahead of print
 Degree: -

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Project name : -
Grant ID : DNRF117
Funding program : -
Funding organization : Danish National Research Foundation
Project name : -
Grant ID : 2009(2)‐72
Funding program : -
Funding organization : Dutch Brain Foundation
Project name : The plasticity of parental caregiving: Characterizing the brain mechanisms underlying normal and disrupted development of parenting / CAREGIVING
Grant ID : 615539
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : NORTE‐01‐0145‐FEDER‐000023
Funding program : European Regional Development Fund
Funding organization : European Commission (EC)
Project name : Human Brain Project Specific Grant Agreement 2 / HBP SGA2
Grant ID : 785907
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : Spanish National Project Complexity of Brain States
Grant ID : PSI2016‐75688‐P
Funding program : -
Funding organization : Spanish Research Agency (AEI) and the European Regional Development Fund (ERDF)
Project name : -
Grant ID : 016.126.059
Funding program : VENI‐Grant
Funding organization : The Netherlands Organisation for Health Research and Development (ZonMw)

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 40 (9) Sequence Number: - Start / End Page: 2771 - 2786 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686