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  Somatosensory stimulation with XNKQ acupuncture modulates functional connectivity of motor areas

Nierhaus, T., Chang, Y., Liu, B., Shi, X., Yi, M., Witt, C. M., et al. (2019). Somatosensory stimulation with XNKQ acupuncture modulates functional connectivity of motor areas. Frontiers in Neuroscience, 13: 147. doi:10.3389/fnins.2019.00147.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-4293-C Version Permalink: http://hdl.handle.net/21.11116/0000-0003-75D3-B
Genre: Journal Article

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 Creators:
Nierhaus, Till1, 2, Author              
Chang, Yinghui 3, 4, Author
Liu, Bin3, Author
Shi, Xuemin 3, Author
Yi, Ming5, 6, Author
Witt, Claudia M. 4, 7, Author
Pach, Daniel 4, 7, Author
Affiliations:
1Department of Education and Psychology, FU Berlin, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
3First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, China, ou_persistent22              
4Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medicine Berlin, Germany, ou_persistent22              
5Department of Neurobiology, School of Basic Medical Sciences, Peking University, China, ou_persistent22              
6Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, China, ou_persistent22              
7Institute for Complementary and Integrative Medicine, University Hospital Zurich, Switzerland, ou_persistent22              

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Free keywords: Resting-state fMRI; Acupuncture; Functional connectivity; Centrality; Stroke; Red nucleus; Precuneus
 Abstract: Xingnao Kaiqiao (XNKQ) acupuncture is an acupuncture technique used for stroke patients. In 24 healthy volunteers, we applied this complex acupuncture intervention, which consists of a manual needle-stimulation on five acupuncture points (DU26 unilaterally, PC6, and SP6 bilaterally). XNKQ was compared to three control conditions: (1) insertion of needles on the XNKQ acupuncture points without stimulation, (2) manual needle-stimulation on five nearby non-acupuncture points, and (3) insertion of needles on the non-acupuncture points without stimulation. In a within-subject design, we investigated functional connectivity changes in resting-state functional magnetic resonance imaging (fMRI) by means of the data-driven eigenvector centrality (EC) approach. With a 2 × 2 factorial within-subjects design with two-factor stimulation (stimulation vs. non-stimulation) and location (acupuncture points vs. non-acupuncture points), we found decreased EC in the precuneus after needle-stimulation (stimulation<non-stimulation), whereas the factor location showed no statistically significant EC differences. XNKQ acupuncture compared with needle-stimulation on non-acupuncture points showed decreased EC primarily in subcortical structures such as the caudate nucleus, subthalamic nucleus, and red nucleus. Post-hoc seed-based analysis revealed that the decrease in EC was mainly driven by reduced temporal correlation to primary sensorimotor cortices. The comparison of XNKQ acupuncture with the other two (non-stimulation) interventions showed no significant differences in EC. Our findings support the importance of the stimulation component of the acupuncture intervention and hint toward the modulation of functional connectivity by XNKQ acupuncture, especially in areas involved in motor function. As a next step, similar mechanisms should be validated in stroke patients suffering from motor deficits.

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Language(s): eng - English
 Dates: 2018-11-192019-02-082019-03-11
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3389/fnins.2019.00147
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Funding organization : First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

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Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 13 Sequence Number: 147 Start / End Page: - Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548