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  Neuroscientific applications of high-field MRI in humans

Turner, R. (2012). Neuroscientific applications of high-field MRI in humans. In J. Hennig (Ed.), High-field MR imaging (pp. 137-149). Berlin: Springer. doi:10.1007/174_2010_103.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-42A8-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-42A9-4
Genre: Book Chapter

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 Creators:
Turner, Robert1, Author              
Affiliations:
1Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              

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Free keywords: Fractional Anisotropy; Cortical Area; Brodmann Area; Grey Matter Density; Isotropic Resolution
 Abstract: The chief advantages of using high-field MRI for neuroscientific research are the improvements in spatial resolution and contrast that become available. Neuroscientists are interested in the spatial organisation of brain grey matter, in cortex and deep brain structures, and in the connectivity of white matter neuronal fibres. At lower field, it is very hard to distinguish cortical areas purely by their anatomical differences, or to discriminate subcomponents of basal ganglia and thalamus. This has led to a widely accepted method of functional image analysis involving warping of individual brains to a standardised template, together with significant image smoothing, which eliminates the possibility of detailed MRI-based mapping of human brain, and severely handicaps the exploration of individual differences and monitoring of brain changes over time. Even at a field of 3 T, the spatial resolution of MR tractography is limited to about 1.5 mm isotropic, hindering discrimination of crossing fibres. However, at fields of 7 T and above, the available high isotropic resolution of 0.4 mm and the varying myelin content of grey matter allow several cortical areas to be quite easily distinguished, and the varying iron content of deeper brain structures reveals their internal features. Higher spatial isotropic resolution in tractography can also be achieved, of 1 mm or better. Because blood oxygenation-dependent contrast (BOLD) also improves at high field, functional maps with submillimetre resolution can be acquired, showing columnar structures such as ocular dominance and orientation columns. These results will enable a much more precise correlation of brain functions with the neural tissue that supports them, and is likely to bring about major conceptual changes in systems neuroscience, especially in analysis methodology.

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Language(s): eng - English
 Dates: 2011-08-312012
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1007/174_2010_103
 Degree: -

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Title: High-field MR imaging
Source Genre: Book
 Creator(s):
Hennig, Jürgen1, Editor
Speck, Oliver 1, Author
Baert, Albert L. 1, Author
Affiliations:
1 External Organizations, ou_persistent22            
Publ. Info: Berlin : Springer
Pages: X, 262 S. Volume / Issue: - Sequence Number: - Start / End Page: 137 - 149 Identifier: ISBN: 978-3-540-85087-8
ISBN: 978-3-540-85090-8