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  Inverse relationship between amplitude and latency of physiological mirror activity during repetitive isometric contractions

Maudrich, T., Kenville, R., Nikulin, V. V., Maudrich, D., Villringer, A., & Ragert, P. (2019). Inverse relationship between amplitude and latency of physiological mirror activity during repetitive isometric contractions. Neuroscience, 406, 300-313. doi:10.1016/j.neuroscience.2019.03.029.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-47D5-D Version Permalink: http://hdl.handle.net/21.11116/0000-0003-8A57-0
Genre: Journal Article

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Maudrich_Kenville_Nikulin_2019.pdf (Publisher version), 3MB
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 Creators:
Maudrich, Tom1, 2, Author              
Kenville, Rouven1, 2, Author              
Nikulin, Vadim V.2, 3, 4, Author              
Maudrich, Dennis2, Author              
Villringer, Arno2, 5, 6, Author              
Ragert, Patrick1, 2, Author              
Affiliations:
1Institute of General Kinesiology and Athletics Training, University of Leipzig, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
3Centre for Cognition and Decision Making, National Research University Higher School of Economics, Moscow, Russia, ou_persistent22              
4Neurophysics Group, Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
6Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              

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Free keywords: EMG; Latency; Mirror activity; Motor overflow; tDCS
 Abstract: Mirror Activity (MA) is a phenomenon that is characterized by involuntarily occurring muscular activity in homologous contralateral limbs during unilateral movements. Even in neurologically healthy humans, MA of a small extent has been described, which does not directly lead to visible movements, but nonetheless, it is still detectable with surface electromyography (EMG) and therefore defined as physiological MA (pMA). The present study investigated latency- and amplitude-characteristics of pMA during repetitive unimanual isometric contractions with high but constant force requirements (80% maximum force). Here, we show for the first time that pMA is not time-locked to the muscle onset of voluntarily contracting hand muscles but starts with varying and dynamically changing latencies. Following consecutive isometric unilateral contractions, the latency of pMA progressively decreases accompanied by a progressive linear increase in its amplitude possibly as a result of changes in inhibitory mechanisms involved in suppressing involuntarily occurring muscular activity. Overall, the latency and amplitude of pMA show a strong inverse relationship. Furthermore, based on the previously proposed hypothesis of motor overflow, we explored the possibility of pMA modulation through anodal and cathodal transcranial direct current stimulation (tDCS) applied to the ipsilateral primary motor cortex (M1), relative to a voluntarily contracting hand. Neither anodal nor cathodal tDCS is able to modulate amplitude or latency of pMA compared to sham tDCS. In conclusion, our results extend the existing knowledge of pMA occurring due to high-effort unilateral contractions with constant force requirements to the aspect of its latency and the inverse association with its amplitude.

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Language(s): eng - English
 Dates: 2018-11-272019-03-122019-03-212019-05-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroscience.2019.03.029
PMID: 30904662
PII: S0306-4522(19)30180-0
Other: Epub ahead of print
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Funding organization : Max-Planck Society
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Grant ID : -
Funding program : Russian Academic Excellence Project 5–100
Funding organization : Ministry of Science and Higher Education of the Russian Federation

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Title: Neuroscience
Source Genre: Journal
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Publ. Info: Oxford : Pergamon
Pages: - Volume / Issue: 406 Sequence Number: - Start / End Page: 300 - 313 Identifier: ISSN: 0306-4522
CoNE: https://pure.mpg.de/cone/journals/resource/954925514498