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  CCL17 exerts a neuroimmune modulatory function and is expressed in hippocampal neurons

Fuelle, L., Offermann, N., Hansen, J. N., Breithausen, B., Erazo, A. B., Schanz, O., et al. (2018). CCL17 exerts a neuroimmune modulatory function and is expressed in hippocampal neurons. Glia, 66(10), 2246-2261. doi:10.1002/glia.23507.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0003-4AD5-A Versions-Permalink: https://hdl.handle.net/21.11116/0000-0003-4AD6-9
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 Urheber:
Fuelle, Lorenz1, Autor
Offermann, Nina1, Autor
Hansen, Jan Niklas2, Autor
Breithausen, Bjoern1, Autor
Erazo, Anna Belen1, Autor
Schanz, Oliver1, Autor
Radau, Luca1, Autor
Gondorf, Fabian1, Autor
Knoepper, Konrad1, Autor
Alferink, Judith1, Autor
Abdullah, Zeinab1, Autor
Neumann, Harald1, Autor
Weighardt, Heike1, Autor
Henneberger, Christian1, Autor
Halle, Annett2, Autor
Foerster, Irmgard1, Autor
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Research Group Neuroimmunology, Center of Advanced European Studies and Research (caesar), Max Planck Society, Ludwig-Erhard-Allee 2, 53175 Bonn, DE, ou_2173684              

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 Zusammenfassung: Chemokines are important signaling molecules in the immune and nervous system. Using a fluorescence reporter mouse model, we demonstrate that the chemokine CCL17, a ligand of the chemokine receptor CCR4, is produced in the murine brain, particularly in a subset of hippocampal CA1 neurons. We found that basal expression of Ccl17 in hippocampal neurons was strongly enhanced by peripheral challenge with lipopolysaccharide (LPS). LPS-mediated induction of Ccl17 in the hippocampus was dependent on local tumor necrosis factor (TNF) signaling, whereas upregulation of Ccl22 required granulocyte-macrophage colony-stimulating factor (GM-CSF). CCL17 deficiency resulted in a diminished microglia density under homeostatic and inflammatory conditions. Further, microglia from naive Ccl17-deficient mice possessed a reduced cellular volume and a more polarized process tree as assessed by computer-assisted imaging analysis. Regarding the overall branching, cell surface area, and total tree length, the morphology of microglia from naive Ccl17-deficient mice resembled that of microglia from wild-type mice after LPS stimulation. In line, electrophysiological recordings indicated that CCL17 downmodulates basal synaptic transmission at CA3-CA1 Schaffer collaterals in acute slices from naive but not LPS-treated animals. Taken together, our data identify CCL17 as a homeostatic and inducible neuromodulatory chemokine affecting the presence and morphology of microglia and synaptic transmission in the hippocampus.

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 Datum: 2018
 Publikationsstatus: Erschienen
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 Identifikatoren: ISI: 000450312100015
DOI: 10.1002/glia.23507
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Quelle 1

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Titel: Glia
  Andere : Glia
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: New York, N.Y. : Wiley-Liss, Inc.
Seiten: - Band / Heft: 66 (10) Artikelnummer: - Start- / Endseite: 2246 - 2261 Identifikator: ISSN: 0894-1491
CoNE: https://pure.mpg.de/cone/journals/resource/954925558509