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  Cannabinoid receptor 2-deficiency ameliorates disease symptoms in a mouse model with Alzheimer's disease-like pathology

Schmoele, A.-C., Lundt, R., Toporowski, G., Hansen, J. N., Beins, E., Halle, A., & Zimmer, A. (2018). Cannabinoid receptor 2-deficiency ameliorates disease symptoms in a mouse model with Alzheimer's disease-like pathology. Journal of Alzheimer's Disease, 64(2), 379-392. doi:10.3233/JAD-180230.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0003-4AD3-C 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0008-897B-4
資料種別: 学術論文

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 作成者:
Schmoele, Anne-Caroline1, 著者
Lundt, Ramona1, 著者
Toporowski, Gregor1, 著者
Hansen, Jan N.2, 著者
Beins, Eva1, 著者
Halle, Annett2, 著者
Zimmer, Andreas1, 著者
所属:
1External Organizations, ou_persistent22              
2Max Planck Research Group Neuroimmunology, Center of Advanced European Studies and Research (caesar), Max Planck Society, Ludwig-Erhard-Allee 2, 53175 Bonn, DE, ou_2173684              

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キーワード: -
 要旨: It is widely accepted that the endocannabinoid system (ECS) is a modulator of neuroinflammation associated with neurodegenerative disorders, including Alzheimer's disease (AD). Thus, expression of the cannabinoid receptor 2 (CB2) is induced in plaque-associated microglia and astrocytes in brain tissues from AD patients and in genetic mouse models expressing pathogenic variants of the amyloid precursor protein (APP). However, the exact mechanism of CB2 signaling in this mouse model remains elusive, because the genetic deletion of CB2 and the pharmacological activation of CB2 both reduced neuroinflammation. Here, we demonstrate that CB2 deletion also improved cognitive and learning deficits in APP/PS1*CB2(-/-) mice. This was accompanied by reduced neuronal loss and decreased plaque levels and coincided with increased expression of A beta degrading enzymes. Interestingly, plaque-associated microglia in APP/PS1*CB2(-/-) mice showed a less activated morphology, while plaques were smaller and more condensed than in APP/PS1 mice. Taken together, these results indicate a beneficial effect of CB2-deficiency in APP transgenic mice. CB2 appears to be part of a protective system that may be detrimental when engaged continuously.

資料詳細

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言語: eng - English
 日付: 2018
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: ISI: 000435572800006
DOI: 10.3233/JAD-180230
 学位: -

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出版物 1

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出版物名: Journal of Alzheimer's Disease
  省略形 : J Alzheimers Dis
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: Amsterdam : IOS Press
ページ: - 巻号: 64 (2) 通巻号: - 開始・終了ページ: 379 - 392 識別子（ISBN, ISSN, DOIなど）: ISSN: 1387-2877
CoNE: https://pure.mpg.de/cone/journals/resource/1387-2877