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  Temporal and reversible control of a DNAzyme by orthogonal photoswitching

Haydell, M. W., Centola, M., Adam, V., Valero, J., & Famulok, M. (2018). Temporal and reversible control of a DNAzyme by orthogonal photoswitching. Journal of the American Chemical Society, 140(49), 16868-16872. doi:10.1021/jacs.8b08738.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0003-53E3-F Version Permalink: https://hdl.handle.net/21.11116/0000-0008-863A-0
Genre: Journal Article

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https://pubs.acs.org/doi/10.1021/jacs.8b08738 (Abstract)
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 Creators:
Haydell, Michael W.1, Author
Centola, Mathias1, Author
Adam, Volker1, Author
Valero, Julian2, Author
Famulok, Michael2, Author
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Fellow Chemical Biology, Center of Advanced European Studies and Research (caesar), Max Planck Society, Ludwig-Erhard-Allee 2, 53175 Bonn, DE, ou_2173681              

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 Abstract: The reversible switching of catalytic systems capable of performing complex DNA computing operations using the temporal control of two orthogonal photoswitches is described. Two distinct photoresponsive molecules have been separately incorporated into a split horseradish peroxidase-mimicking DNAzyme. We show that its catalytic function can be turned on and off reversibly upon irradiation with specific wavelengths of light. The system responds orthogonally to a selection of irradiation wavelengths and durations of irradiation. Furthermore, the DNAzyme exhibits reversible switching and retains this ability throughout multiple switching cycles. We apply our system as a light-controlled 4:2 multiplexer. Orthogonally photoswitchable DNAzyme-based catalysts as introduced here have potential use for controlling complex logical operations and for future applications in DNA nanodevices.

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Language(s): eng - English
 Dates: 2018-11-16
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000453488500001
DOI: 10.1021/jacs.8b08738
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Title: Journal of the American Chemical Society
  Abbreviation : J Am Chem Soc
  Other : JACS
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 140 (49) Sequence Number: - Start / End Page: 16868 - 16872 Identifier: ISSN: 0002-7863
CoNE: https://pure.mpg.de/cone/journals/resource/954925376870