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  Dissociating semantic and phonological contributions of the left inferior frontal gyrus to language production

Klaus, J., & Hartwigsen, G. (2019). Dissociating semantic and phonological contributions of the left inferior frontal gyrus to language production. Human Brain Mapping, 40(11), 3279-3287. doi:10.1002/hbm.24597.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-4FB2-C Version Permalink: http://hdl.handle.net/21.11116/0000-0004-401E-3
Genre: Journal Article

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 Creators:
Klaus, Jana1, 2, Author              
Hartwigsen, Gesa1, 2, Author              
Affiliations:
1Lise Meitner Research Group Cognition and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3025665              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634551              

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Free keywords: Repetitive transcranial magnetic stimulation; Virtual lesion; Prefrontal cortex; Word; Generation; Broca
 Abstract: While the involvement of the left inferior frontal gyrus (IFG) in language production is undisputed, the role of specific subregions at different representational levels remains unclear. Some studies suggest a division of anterior and posterior regions for semantic and phonological processing, respectively. Crucially, evidence thus far only comes from correlative neuroimaging studies, but the functional relevance of the involvement of these subregions during a given task remains elusive. We applied repetitive transcranial magnetic stimulation (rTMS) over anterior and posterior IFG (aIFG/pIFG), and vertex as a control site, while participants performed a category member and a rhyme generation task. We found a functional-anatomical double dissociation between tasks and subregions. Naming latencies were significantly delayed in the semantic task when rTMS was applied to aIFG (relative to pIFG and vertex). In contrast, we observed a facilitation of naming latencies in the phonological task when rTMS was applied to pIFG (relative to aIFG and vertex). The results provide first causal evidence for the notion that anterior portions of the IFG are selectively recruited for semantic processing while posterior regions are functionally specific for phonological processing during word production. These findings shed light on the functional parcellation of the left IFG in language production.

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Language(s): eng - English
 Dates: 2019-04-012018-11-102019-04-022019-04-102019-08-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/hbm.24597
PMID: 30969004
Other: Epub 2019
 Degree: -

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Project name : -
Grant ID : HA 6314/3‐1
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : HA 6314/4‐1
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : KL 2933/3‐1
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max Planck Society

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 40 (11) Sequence Number: - Start / End Page: 3279 - 3287 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686