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  The hippocampus encodes distances in multidimensional feature space

Theves, S., Fernandez, G., & Doeller, C. F. (2019). The hippocampus encodes distances in multidimensional feature space. Current Biology, 29(7), 1226-1231.e3. doi:10.1016/j.cub.2019.02.035.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0003-4F71-6 Version Permalink: https://hdl.handle.net/21.11116/0000-0010-0AC6-4
Genre: Journal Article

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Locator:
https://www.sciencedirect.com/science/article/pii/S0960982219302052?via%3Dihub (Publisher version)
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Under an Elsevier user license
OA-Status:
Green

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 Creators:
Theves, Stephanie1, 2, Author           
Fernandez, Guillén2, Author
Doeller, Christian F.1, 3, Author           
Affiliations:
1Department Psychology (Doeller), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2591710              
2Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
3Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, Kavli Institute, Norwegian University of Science and Technology, Trondheim, Norway, ou_persistent22              

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Free keywords: Cognitive geometry; Cognitive map; Conceptual knowledge; Spatial coding
 Abstract: The hippocampal formation encodes maps of the physical environment [1, 2, 3, 4, 5]. A key question in neuroscience is whether its spatial coding principles also provide a universal metric for the organization of non-spatial information. Initial evidence comes from studies revealing directional modulation of fMRI responses in humans [6, 7] during navigation through abstract spaces and the involvement of place and grid cells in encoding of non-spatial feature dimensions [8]. However, a critical feature of a map-like representation is information about distances between locations, which has yet only been demonstrated for physical space [4, 9]. Here, we probe whether the hippocampus similarly encodes distances between points in an abstract space spanned by continuous stimulus-feature dimensions that were relevant to the acquisition of a novel concept. We find that, after learning, two-dimensional distances between individual positions in the abstract space were represented in the hippocampal multivoxel pattern as well as in the univariate hippocampal signal as indexed by fMRI adaptation. These results support the notion that the hippocampus computes domain-general, multidimensional cognitive maps along continuous dimensions.

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Language(s): eng - English
 Dates: 2018-12-132018-06-122019-02-142019-03-212019-04-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.cub.2019.02.035
PMID: 30905602
Other: epub 2019
 Degree: -

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Project name : -
Grant ID : NWO-Gravitation 024-001-006
Funding program : -
Funding organization : Netherlands Organisation for Scientific Research (NWO)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max Planck Society
Project name : -
Grant ID : -
Funding program : -
Funding organization : Kavli Foundation
Project name : Cognitive Geometry: Deciphering neural concept spaces and engineering knowledge to empower smart brains in a smart society / GEOCOG
Grant ID : 724836
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : 223262/F50
Funding program : -
Funding organization : Centre of Excellence scheme of the Research Council of Norway – Centre for Neural Computation
Project name : -
Grant ID : -
Funding program : -
Funding organization : The Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits
Project name : NORBRAIN
Grant ID : 197467/F50
Funding program : National Infrastructure scheme of the Research Council of Norway
Funding organization : Research Council of Norway
Project name : -
Grant ID : NWO-Vidi 452-12-009
Funding program : -
Funding organization : Netherlands Organisation for Scientific Research (NWO)
Project name : -
Grant ID : NWO-MaGW 406-14-114
Funding program : -
Funding organization : Netherlands Organisation for Scientific Research (NWO)
Project name : -
Grant ID : NWO-MaGW 406-15-291
Funding program : -
Funding organization : Netherlands Organisation for Scientific Research (NWO)

Source 1

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Title: Current Biology
  Other : Curr. Biol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London, UK : Cell Press
Pages: - Volume / Issue: 29 (7) Sequence Number: - Start / End Page: 1226 - 1231.e3 Identifier: ISSN: 0960-9822
CoNE: https://pure.mpg.de/cone/journals/resource/954925579107