English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse
  1. Item Summary / 
  2. View item

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  New role of P2X7 receptor in an Alzheimer's disease mouse model

Martin, E., Amar, M., Dalle, C., Youssef, I., Boucher, C., Le Duigou, C., et al. (2019). New role of P2X7 receptor in an Alzheimer's disease mouse model. Molecular Psychiatry, 24(1), 108-125. doi:10.1038/s41380-018-0108-3.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-0003-525D-9 Version Permalink: https://hdl.handle.net/21.11116/0000-0006-0CD8-A
Genre: Journal Article

Files

show Files
hide Files
:
s41380-018-0108-3.pdf (Publisher version), 5MB
View   Save
File Permalink:
https://hdl.handle.net/21.11116/0000-0003-525F-7
Name:
s41380-018-0108-3.pdf
Description:
Open Access
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
View
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Locator:
https://www.nature.com/articles/s41380-018-0108-3 (Abstract)
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Martin, Elodie1, Author
Amar, Majid1, Author
Dalle, Carine1, Author
Youssef, Ihsen1, Author
Boucher, Celine1, Author
Le Duigou, Caroline1, Author
Brueckner, Matthias2, Author
Prigent, Annick1, Author
Sazdovitch, Veronique1, Author
Halle, Annett2, Author
Kanellopoulos, Jean M.1, Author
Fontaine, Bertrand1, Author
Delatour, Benoit1, Author
Delarasse, Cecile1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Research Group Neuroimmunology, Center of Advanced European Studies and Research (caesar), Max Planck Society, Ludwig-Erhard-Allee 2, 53175 Bonn, DE, ou_2173684              

Content

show
hide
Free keywords: P2Y(2) NUCLEOTIDE RECEPTORS; PURINERGIC P2X(7) RECEPTOR; CENTRAL-NERVOUS-SYSTEM; CHEMOKINE RECEPTORS; APOPTOTIC CELLS; AMYLOID PLAQUES; COMMON VARIANTS; T-CELLS; MICROGLIA; NEUROINFLAMMATION
 Abstract: Extracellular aggregates of amyloid β (Aβ) peptides, which are characteristic of Alzheimer's disease (AD), act as an essential trigger for glial cell activation and the release of ATP, leading to the stimulation of purinergic receptors, especially the P2X7 receptor (P2X7R). However, the involvement of P2X7R in the development of AD is still ill-defined regarding the dual properties of this receptor. Particularly, P2X7R activates the NLRP3 inflammasome leading to the release of the pro-inflammatory cytokine, IL-1β; however, P2X7R also induces cleavage of the amyloid precursor protein generating Aβ peptides or the neuroprotective fragment sAPPα. We thus explored in detail the functions of P2X7R in AD transgenic mice. Here, we show that P2X7R deficiency reduced Aβ lesions, rescued cognitive deficits and improved synaptic plasticity in AD mice. However, the lack of P2X7R did not significantly affect the release of IL-1β or the levels of non-amyloidogenic fragment, sAPPα, in AD mice. Instead, our results show that P2X7R plays a critical role in Aβ peptide-mediated release of chemokines, particularly CCL3, which is associated with pathogenic CD8+ T cell recruitment. In conclusion, our study highlights a novel detrimental function of P2X7R in chemokine release and supports the notion that P2X7R may be a promising therapeutic target for AD.

Details

show
hide
Language(s): eng - English
 Dates: 2018-06-222019-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000455092300008
DOI: 10.1038/s41380-018-0108-3
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Molecular Psychiatry
  Abbreviation : Mol Psychiatry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Houndmills, Hampshire, UK : Stockton Press
Pages: - Volume / Issue: 24 (1) Sequence Number: - Start / End Page: 108 - 125 Identifier: ISSN: 1359-4184
CoNE: https://pure.mpg.de/cone/journals/resource/954925619131