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  Spontaneous center formation in Dictyostelium discoideum

Vidal-Henriquez, E., & Gholami, A. (2019). Spontaneous center formation in Dictyostelium discoideum. Scientific Reports, 9: 3935. doi:10.1038/s41598-019-40373-4.

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Vidal-Henriquez, Estefania1, Author              
Gholami, Azam1, Author              
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1Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063287              

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 Abstract: Dictyostelium discoideum (D.d.) is a widely studied amoeba due to its capabilities of development, survival, and self-organization. During aggregation it produces and relays a chemical signal (cAMP) which shows spirals and target centers. Nevertheless, the natural emergence of these structures is still not well understood. We present a mechanism for creation of centers and target waves of cAMP in D.d. by adding cell inhomogeneity to a well known reaction-diffusion model of cAMP waves and we characterize its properties. We show how stable activity centers appear spontaneously in areas of higher cell density with the oscillation frequency of these centers depending on their density. The cAMP waves have the characteristic dispersion relation of trigger waves and a velocity which increases with cell density. Chemotactically competent cells react to these waves and create aggregation streams even with very simple movement rules. Finally we argue in favor of the existence of bounded phosphodiesterase to maintain the wave properties once small cell clusters appear.

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Language(s): eng - English
 Dates: 2019
 Publication Status: Published online
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41598-019-40373-4
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Title: Scientific Reports
Source Genre: Journal
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Pages: 11 Volume / Issue: 9 Sequence Number: 3935 Start / End Page: - Identifier: -