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Free keywords:
nuclear pore complex, NPC, nucleoporin, nuclear transport, NPC architecture, NPC assembly
Abstract:
Nuclear pore complexes (NPCs) mediate nucleocytoplasmic exchange.They are exceptionally large protein complexes that fuse the inner andouter nuclear membranes to form channels across the nuclear envelope.About 30 different protein components, termed nucleoporins, assemble inmultiple copies into an intricate cylindrical architecture. Here, we reviewour current knowledge of the structure of nucleoporins and how those cometogether in situ. We delineate architectural principles on several hierarchicalorganization levels, including isoforms, posttranslational modifications, nu-cleoporins, and higher-order oligomerization of nucleoporin subcomplexes.We discuss how cells exploit this modularity to faithfully assemble NPC.
