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  Generation of two human isogenic iPSC lines from fetal dermal fibroblasts

Tandon, R., Brändl, B., Baryshnikova, N., Landshammer, A., Steenpaß, L., Keminer, O., et al. (2018). Generation of two human isogenic iPSC lines from fetal dermal fibroblasts. Stem Cell Research, 33, 120-124. doi:10.1016/j.scr.2018.10.004.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-5810-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-8E2B-E
Genre: Journal Article

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 Creators:
Tandon, Rashmi , Author
Brändl, Björn1, Author              
Baryshnikova, Natalya , Author
Landshammer, Alexandro1, Author              
Steenpaß, Laura , Author
Keminer, Oliver , Author
Pless, Ole , Author
Müller, Franz-Josef2, Author              
Affiliations:
1Dept. of Genome Regulation (Head: Alexander Meissner), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2379694              
2Cellular Phenotyping (Franz-Josef Müller), Dept. of Genome Regulation, (Head: Alexander Meissner), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_3014190              

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 Abstract: Two isogenic hiPSC lines, ZIPi013-B and ZIPi013-E, were generated by reprogramming fetal dermal fibroblasts with episomal vectors. Previously, the same fetal fibroblasts were reprogrammed multiple times in a study comparing other reprogramming methods. As a consequence, the genomes have been sequenced multiple times. Both new cell lines offer the opportunity to study basic stem cell biology and model human disease. They can be applied as reference cell lines for creating isogenic clones bearing disease mutations on a well-characterized genomic background, as both cell lines have demonstrated excellent differentiation capacity in multiple labs.

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Language(s): eng - English
 Dates: 2018-10-022018-10-122018-12
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1016/j.scr.2018.10.004
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Title: Stem Cell Research
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: 5 Volume / Issue: 33 Sequence Number: - Start / End Page: 120 - 124 Identifier: ISSN: 1873-5061
CoNE: https://pure.mpg.de/cone/journals/resource/1873-5061