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  Characterization of a human genomic DNA fragment coding for a myosin heavy chain

Appelhans, H., & Vosberg, H.-P. (1983). Characterization of a human genomic DNA fragment coding for a myosin heavy chain. Human Genetics, 65(2), 198-203. doi:10.1007/BF00286664.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0003-59D0-E Version Permalink: https://hdl.handle.net/21.11116/0000-0003-59D1-D
Genre: Journal Article

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HumanGenet_65_1983_198.pdf (Any fulltext), 879KB
 
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 Creators:
Appelhans, Heribert1, Author           
Vosberg, Hans-Peter2, Author           
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1Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: A DNA segment from the human genome with information for myosin heavy chain (MHC) was isolated from a human genomic DNA library cloned in lambda Charon 4A phages. The isolation was accomplished by a myosin cDNA probe obtained from rabbit heart muscle mRNA (Sinha et al. 1982). The selected human DNA clone, designated lambda gMHC1, contains a genomic DNA fragment of about 14 kilobase pairs. The transcriptional polarity of this DNA was determined. The 5'-end of the gene is missing from the cloned fragment. This human gene exhibits sequence homology to MHC DNA of rabbit and chicken, but not to an MHC sequence of nematode. The isolated gene fragment is a member of the human MHC multi-gene family, which is presumed to consist of probably more than ten separate sarcomeric MHC genes per haploid genome.

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Language(s): eng - English
 Dates: 1983-09-301983-12
 Publication Status: Issued
 Pages: 6
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/BF00286664
URI: https://www.ncbi.nlm.nih.gov/pubmed/6654335
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Title: Human Genetics
Source Genre: Journal
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Publ. Info: Berlin : Springer-Verlag
Pages: - Volume / Issue: 65 (2) Sequence Number: - Start / End Page: 198 - 203 Identifier: ISSN: 0340-6717
CoNE: https://pure.mpg.de/cone/journals/resource/954925519623