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  MR spectroscopy of the cervical spinal cord in chronic spinal cord injury

Wyss, P. O., Huber, E., Curt, A., Kollias, S., Freund, P., & Henning, A. (2019). MR spectroscopy of the cervical spinal cord in chronic spinal cord injury. Radiology, 291(1), 131-138. doi:10.1148/radiol.2018181037.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-5B40-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9A47-0
Genre: Journal Article

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 Creators:
Wyss, Patrik O. 1, 2, 3, Author
Huber, Eveline4, Author
Curt, Armin 4, Author
Kollias, Spyros 5, Author
Freund, Patrick4, 6, 7, Author              
Henning, Anke 1, 3, 8, Author
Affiliations:
1Institute for Biomedical Engineering, University of Zurich, Switzerland, ou_persistent22              
2Department of Radiology, Swiss Paraplegic Research (SPF), Nottwill, Switzerland, ou_persistent22              
3Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ou_persistent22              
4Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
5Institute of Neuroradiology, University Hospital Zurich, Switzerland, ou_persistent22              
6Department of Brain Repair & Rehabilitation, University College London, United Kingdom, ou_persistent22              
7Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
8Institute of Physics, Ernst Moritz Arndt University of Greifswald, Germany, ou_persistent22              

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 Abstract: Purpose To investigate metabolic changes in chronic spinal cord injury (SCI) by applying MR spectroscopy in the cervical spinal cord. Materials and Methods Single-voxel short-echo spectroscopic data in study participants with chronic SCI and healthy control subjects were prospectively acquired in the cervical spinal cord at C2 above the level of injury between March 2016 and January 2017 and were compared between groups. Concentrations of total N-acetylaspartate (tNAA), myo-inositol (mI), total choline-containing compounds (tCho), creatine, and glutamine and glutamate complex were estimated from the acquired spectra. Participants were assessed with a comprehensive clinical evaluation investigating sensory and motor deficits. Correlation analysis was applied to investigate relationships between observed metabolic differences, lesion severity, and clinical outcome. Results There were 18 male study participants with chronic SCI (median age, 51 years; range, 30-68 years) and 11 male healthy control subjects (median age, 45 years; range, 30-67 years). At cervical level C2, tNAA/mI and tCho/mI ratios were lower in participants with SCI (tNAA/mI: -26%, P = .003; tCho/mI: -18%; P = .04) than in healthy control subjects. The magnitude of difference was greater with the severity of cord atrophy (tNAA/mI: R2 = 0.44, P = .003; tCho/mI: R2 = 0.166, P = .09). Smaller tissue bridges at the lesion site correlated with lower ratios of tNAA/mI (R2 = 0.69, P = .006) and tCho/mI (R2 = 0.51, P = .03) at the C2 level. Lower tNAA/mI and tCho/mI ratios were associated with worse sensory and motor outcomes (P < .05). Conclusion Supralesional metabolic alterations are observed in chronic spinal cord injury, likely reflecting neurodegeneration, demyelination, and astrocytic gliosis in the injured cervical cord. Lesion severity and greater clinical impairment are both linked to the biochemical changes in the atrophied cervical cord after spinal cord injury.

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Language(s): eng - English
 Dates: 2018-06-062018-05-012018-12-032019-04-292019-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1148/radiol.2018181037
PMID: 30694162
Other: Epub 2019
 Degree: -

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Project name : -
Grant ID : 143715
Funding program : -
Funding organization : Swiss National Science Foundation
Project name : -
Grant ID : 2047
Funding program : -
Funding organization : Hartmann Muller-Stiftung fur Medizinische Forschung
Project name : -
Grant ID : -
Funding program : Clinical Research Priority Program (CRPP)
Funding organization : University Zurich
Project name : Imaging synaptic plasticity by ultra-high field magnetic resonance spectroscopy in health and psychiatric disease / SYNAPLAST MR
Grant ID : 679927
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : WFL-CH-007/14
Funding program : -
Funding organization : Wings for Life, Austria

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Title: Radiology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Easton, Pa., etc. : Radiological Society of North America.
Pages: - Volume / Issue: 291 (1) Sequence Number: - Start / End Page: 131 - 138 Identifier: ISSN: 0033-8419
CoNE: https://pure.mpg.de/cone/journals/resource/954925437502