English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
 DetailsSummary
  Mega-analysis of gray matter volume in substance dependence: General and substance-specific regional effects

Mackey, S., Allgaier, N., Chaarani, B., Spechler, P., Orr, C., Bunn, J., et al. (2019). Mega-analysis of gray matter volume in substance dependence: General and substance-specific regional effects. American Journal of Psychiatry, 176(2), 119-128. doi:10.1176/appi.ajp.2018.17040415.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-0003-5BEF-B Version Permalink: https://hdl.handle.net/21.11116/0000-0003-920A-D
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Mackey, Scott 1, Author
Allgaier, Nicholas 1, Author
Chaarani, Bader 1, Author
Spechler, Philip 1, Author
Orr , Catherine 1, Author
Bunn, Janice 1, Author
Allen, Nicholas B. 1, Author
Alia-Klein , Nelly 1, Author
Batalla, Albert 1, Author
Blaine , Sara 1, Author
Brooks, Samantha 1, Author
Caparelli , Elisabeth1, Author
Chye , Yann Ying 1, Author
Cousijn , Janna 1, Author
Dagher, Alain1, Author
Desrivieres, Sylvane 1, Author
Feldstein-Ewing, Sarah 1, Author
Foxe, John J. 1, Author
Goldstein , Rita Z. 1, Author
Goudriaan, Anna E. 1, Author
Heitzeg, Mary M.1, AuthorHester, Robert 1, AuthorHutchison, Kent 1, AuthorKorucuoglu, Ozlem 1, AuthorLi, Chiang-Shan R. 1, AuthorLondon , Edythe 1, AuthorLorenzetti , Valentina 1, AuthorLuijten , Maartje 1, AuthorMartin-Santos , Rocio 1, AuthorMay, April 1, AuthorMomenan , Reza 1, AuthorMorales , Angelica 1, AuthorPaulus, Martin P. 1, AuthorPearlson , Godfrey 1, AuthorRousseau , Marc-Etienne 1, AuthorSalmeron , Betty Jo 1, AuthorSchluter, Renée 1, AuthorSchmaal , Lianne 1, AuthorSchumann, Gunter 1, AuthorSjoerds, Zsuzsika2, Author           Stein, Dan J. 1, AuthorStein , Elliot A. 1, AuthorSinha , Rajita 1, AuthorSolowij , Nadia 1, AuthorTapert , Susan 1, AuthorUhlmann, Anne 1, AuthorVeltman , Dick 1, Authorvan Holst , Ruth 1, AuthorWhittle , Sarah 1, AuthorWright, Margaret J. 1, AuthorYücel , Murat 1, AuthorZhang, Sheng 1, AuthorYurgelun-Todd , Deborah 1, AuthorHibar , Derrek P. 1, AuthorJahanshad , Neda 1, AuthorEvans , Alan 1, AuthorThompson, Paul M. 1, AuthorGlahn , David C.1, AuthorConrod, Patricia 1, AuthorGaravan , Hugh 1, Authorthe ENIGMA Addiction Working Group, Author               more..
Affiliations:
1External Organizations, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

Content

show
hide
Free keywords: Mega-Analysis; Structural MRI; Substance-Related Disorders
 Abstract: OBJECTIVE::

Although lower brain volume has been routinely observed in individuals with substance dependence compared with nondependent control subjects, the brain regions exhibiting lower volume have not been consistent across studies. In addition, it is not clear whether a common set of regions are involved in substance dependence regardless of the substance used or whether some brain volume effects are substance specific. Resolution of these issues may contribute to the identification of clinically relevant imaging biomarkers. Using pooled data from 14 countries, the authors sought to identify general and substance-specific associations between dependence and regional brain volumes.
METHOD::

Brain structure was examined in a mega-analysis of previously published data pooled from 23 laboratories, including 3,240 individuals, 2,140 of whom had substance dependence on one of five substances: alcohol, nicotine, cocaine, methamphetamine, or cannabis. Subcortical volume and cortical thickness in regions defined by FreeSurfer were compared with nondependent control subjects when all sampled substance categories were combined, as well as separately, while controlling for age, sex, imaging site, and total intracranial volume. Because of extensive associations with alcohol dependence, a secondary contrast was also performed for dependence on all substances except alcohol. An optimized split-half strategy was used to assess the reliability of the findings.
RESULTS::

Lower volume or thickness was observed in many brain regions in individuals with substance dependence. The greatest effects were associated with alcohol use disorder. A set of affected regions related to dependence in general, regardless of the substance, included the insula and the medial orbitofrontal cortex. Furthermore, a support vector machine multivariate classification of regional brain volumes successfully classified individuals with substance dependence on alcohol or nicotine relative to nondependent control subjects.
CONCLUSIONS::

The results indicate that dependence on a range of different substances shares a common neural substrate and that differential patterns of regional volume could serve as useful biomarkers of dependence on alcohol and nicotine.

Details

show
hide
Language(s): eng - English
 Dates: 2018-03-202017-04-122018-07-232018-10-192019-02-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1176/appi.ajp.2018.17040415
PMID: 30336705
PMC: PMC6427822
Other: Epub 2018
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : -
Grant ID : 1R21DA038381 ; R01-DA014100 ; R01AA021449 ; R01DA023248 ; K25DA040032 ; R01 DA020726 ; T32 DA024635 ; PL30-1DA024859-01
Funding program : NIDA Grant
Funding organization : National Institute on Drug Abuse (NIDA)
Project name : -
Grant ID : U54 EB 020403 ; R01 DA018307
Funding program : -
Funding organization : National Institutes of Health (NIH)
Project name : -
Grant ID : 453.08.01
Funding program : VICI Grant
Funding organization : Netherlands Organization for Scientific Research (NWO)
Project name : -
Grant ID : 31160003 ; 31160004 ; 91676084 ; 31180002
Funding program : -
Funding organization : The Netherlands Organization for Health Research and Development (ZonMW)
Project name : -
Grant ID : 016.08.322
Funding program : VIDI Grant
Funding organization : Netherlands Organization for Scientific Research (NWO)
Project name : -
Grant ID : -
Funding program : Intramural Clinical and Biological Research Program
Funding organization : National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Project name : -
Grant ID : -
Funding program : Intramural Research Program of NIDA
Funding organization : National Institute on Drug Abuse (NIDA)
Project name : -
Grant ID : UL1-RR24925-01
Funding program : -
Funding organization : NIH National Center for Research Resources
Project name : -
Grant ID : R01-AA013892
Funding program : -
Funding organization : National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Project name : -
Grant ID : 459111
Funding program : -
Funding organization : Clive and Vera Ramaciotti Foundation for Biomedical Research National and Health and Medical Research Council
Project name : -
Grant ID : FT110100752
Funding program : Australian Research Council Future Fellowship
Funding organization : Australian Research Council
Project name : -
Grant ID : 1117188
Funding program : National Health and Medical Research Council Fellowship
Funding organization : National Institute of Mental Health (NIMH)
Project name : -
Grant ID : -
Funding program : David Winston Turner Endowment Fund
Funding organization : Monash University

Source 1

show
hide
Title: American Journal of Psychiatry
  Other : Am. J. Psychiat.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Baltimore : American Psychiatric Association
Pages: - Volume / Issue: 176 (2) Sequence Number: - Start / End Page: 119 - 128 Identifier: ISSN: 0002-953X
CoNE: https://pure.mpg.de/cone/journals/resource/110985822459324