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  Mega-analysis of gray matter volume in substance dependence: General and substance-specific regional effects

Mackey, S., Allgaier, N., Chaarani, B., Spechler, P., Orr, C., Bunn, J., et al. (2019). Mega-analysis of gray matter volume in substance dependence: General and substance-specific regional effects. American Journal of Psychiatry, 176(2), 119-128. doi:10.1176/appi.ajp.2018.17040415.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0003-5BEF-B Versions-Permalink: https://hdl.handle.net/21.11116/0000-000D-0595-5
Genre: Zeitschriftenartikel

Externe Referenzen

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externe Referenz:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427822/ (Preprint)
Beschreibung:
-
OA-Status:
Grün

Urheber

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 Urheber:
Mackey, Scott 1, Autor
Allgaier, Nicholas 1, Autor
Chaarani, Bader 1, Autor
Spechler, Philip 1, Autor
Orr , Catherine 1, Autor
Bunn, Janice 1, Autor
Allen, Nicholas B. 1, Autor
Alia-Klein , Nelly 1, Autor
Batalla, Albert 1, Autor
Blaine , Sara 1, Autor
Brooks, Samantha 1, Autor
Caparelli , Elisabeth1, Autor
Chye , Yann Ying 1, Autor
Cousijn , Janna 1, Autor
Dagher, Alain1, Autor
Desrivieres, Sylvane 1, Autor
Feldstein-Ewing, Sarah 1, Autor
Foxe, John J. 1, Autor
Goldstein , Rita Z. 1, Autor
Goudriaan, Anna E. 1, Autor
mehr..
Affiliations:
1External Organizations, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

Inhalt

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Schlagwörter: Mega-Analysis; Structural MRI; Substance-Related Disorders
 Zusammenfassung: OBJECTIVE::

Although lower brain volume has been routinely observed in individuals with substance dependence compared with nondependent control subjects, the brain regions exhibiting lower volume have not been consistent across studies. In addition, it is not clear whether a common set of regions are involved in substance dependence regardless of the substance used or whether some brain volume effects are substance specific. Resolution of these issues may contribute to the identification of clinically relevant imaging biomarkers. Using pooled data from 14 countries, the authors sought to identify general and substance-specific associations between dependence and regional brain volumes.
METHOD::

Brain structure was examined in a mega-analysis of previously published data pooled from 23 laboratories, including 3,240 individuals, 2,140 of whom had substance dependence on one of five substances: alcohol, nicotine, cocaine, methamphetamine, or cannabis. Subcortical volume and cortical thickness in regions defined by FreeSurfer were compared with nondependent control subjects when all sampled substance categories were combined, as well as separately, while controlling for age, sex, imaging site, and total intracranial volume. Because of extensive associations with alcohol dependence, a secondary contrast was also performed for dependence on all substances except alcohol. An optimized split-half strategy was used to assess the reliability of the findings.
RESULTS::

Lower volume or thickness was observed in many brain regions in individuals with substance dependence. The greatest effects were associated with alcohol use disorder. A set of affected regions related to dependence in general, regardless of the substance, included the insula and the medial orbitofrontal cortex. Furthermore, a support vector machine multivariate classification of regional brain volumes successfully classified individuals with substance dependence on alcohol or nicotine relative to nondependent control subjects.
CONCLUSIONS::

The results indicate that dependence on a range of different substances shares a common neural substrate and that differential patterns of regional volume could serve as useful biomarkers of dependence on alcohol and nicotine.

Details

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Sprache(n): eng - English
 Datum: 2018-03-202017-04-122018-07-232018-10-192019-02-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1176/appi.ajp.2018.17040415
PMID: 30336705
PMC: PMC6427822
Anderer: Epub 2018
 Art des Abschluß: -

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Entscheidung

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Projektinformation

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Projektname : -
Grant ID : 1R21DA038381 ; R01-DA014100 ; R01AA021449 ; R01DA023248 ; K25DA040032 ; R01 DA020726 ; T32 DA024635 ; PL30-1DA024859-01
Förderprogramm : NIDA Grant
Förderorganisation : National Institute on Drug Abuse (NIDA)
Projektname : -
Grant ID : U54 EB 020403 ; R01 DA018307
Förderprogramm : -
Förderorganisation : National Institutes of Health (NIH)
Projektname : -
Grant ID : 453.08.01
Förderprogramm : VICI Grant
Förderorganisation : Netherlands Organization for Scientific Research (NWO)
Projektname : -
Grant ID : 31160003 ; 31160004 ; 91676084 ; 31180002
Förderprogramm : -
Förderorganisation : The Netherlands Organization for Health Research and Development (ZonMW)
Projektname : -
Grant ID : 016.08.322
Förderprogramm : VIDI Grant
Förderorganisation : Netherlands Organization for Scientific Research (NWO)
Projektname : -
Grant ID : -
Förderprogramm : Intramural Clinical and Biological Research Program
Förderorganisation : National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Projektname : -
Grant ID : -
Förderprogramm : Intramural Research Program of NIDA
Förderorganisation : National Institute on Drug Abuse (NIDA)
Projektname : -
Grant ID : UL1-RR24925-01
Förderprogramm : -
Förderorganisation : NIH National Center for Research Resources
Projektname : -
Grant ID : R01-AA013892
Förderprogramm : -
Förderorganisation : National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Projektname : -
Grant ID : 459111
Förderprogramm : -
Förderorganisation : Clive and Vera Ramaciotti Foundation for Biomedical Research National and Health and Medical Research Council
Projektname : -
Grant ID : FT110100752
Förderprogramm : Australian Research Council Future Fellowship
Förderorganisation : Australian Research Council
Projektname : -
Grant ID : 1117188
Förderprogramm : National Health and Medical Research Council Fellowship
Förderorganisation : National Institute of Mental Health (NIMH)
Projektname : -
Grant ID : -
Förderprogramm : David Winston Turner Endowment Fund
Förderorganisation : Monash University

Quelle 1

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Titel: American Journal of Psychiatry
  Andere : Am. J. Psychiat.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Baltimore : American Psychiatric Association
Seiten: - Band / Heft: 176 (2) Artikelnummer: - Start- / Endseite: 119 - 128 Identifikator: ISSN: 0002-953X
CoNE: https://pure.mpg.de/cone/journals/resource/110985822459324