English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Methodological consensus on clinical proton MRS of the brain: Review and recommendations

Wilson, M., Andronesi, O., Barker, P., Bartha, R., Bizzi, A., Bolan, P., et al. (2019). Methodological consensus on clinical proton MRS of the brain: Review and recommendations. Magnetic Resonance in Medicine, 82(2), 527-550. doi:10.1002/mrm.27742.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0003-5D22-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-961D-4
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Wilson, M, Author
Andronesi , O, Author
Barker, PB, Author
Bartha, R, Author
Bizzi, A, Author
Bolan, PJ, Author
Brindle, KM, Author
Choi, IY, Author
Cudalbu , C, Author
Dydak, U, Author
Emir, UE, Author
Gonzalez, RG, Author
Gruber, S, Author
Gruetter, R, Author
Gupta, RK, Author
Heerschap , A, Author
Henning, A1, 2, Author              
Hetherington, HP, Author
Huppi, PS, Author
Hurd, RE, Author
Kantarci, K, AuthorKauppinen, RA, AuthorKlomp, DWJ, AuthorKreis, R, AuthorKruiskamp, MJ, AuthorLeach, MO, AuthorLin, AP, AuthorLuijten, PR, AuthorMarjańska, M, AuthorMaudsley, AA, AuthorMeyerhoff, DJ, AuthorMountford, CE, AuthorMullins, PG, AuthorMurdoch, JB, AuthorNelson, SJ, AuthorNoeske, R, AuthorÖz, G, AuthorPan, JW, AuthorPeet, AC, AuthorPoptani , H, AuthorPosse, S, AuthorRatai, EM, AuthorSalibi, T, AuthorScheenen, TWJ, AuthorSmith, ICP, AuthorSoher, PJ, AuthorTkáč , I, AuthorVigneron, DB, AuthorHowe, FA, Author more..
Affiliations:
1Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: Proton MRS (1H MRS) provides noninvasive, quantitative metabolite profiles of tissue and has been shown to aid the clinical management of several brain diseases. Although most modern clinical MR scanners support MRS capabilities, routine use is largely restricted to specialized centers with good access to MR research support. Widespread adoption has been slow for several reasons, and technical challenges toward obtaining reliable good‐quality results have been identified as a contributing factor. Considerable progress has been made by the research community to address many of these challenges, and in this paper a consensus is presented on deficiencies in widely available MRS methodology and validated improvements that are currently in routine use at several clinical research institutions. In particular, the localization error for the PRESS localization sequence was found to be unacceptably high at 3 T, and use of the semi‐adiabatic localization by adiabatic selective refocusing sequence is a recommended solution. Incorporation of simulated metabolite basis sets into analysis routines is recommended for reliably capturing the full spectral detail available from short TE acquisitions. In addition, the importance of achieving a highly homogenous static magnetic field (B0) in the acquisition region is emphasized, and the limitations of current methods and hardware are discussed. Most recommendations require only software improvements, greatly enhancing the capabilities of clinical MRS on existing hardware. Implementation of these recommendations should strengthen current clinical applications and advance progress toward developing and validating new MRS biomarkers for clinical use.

Details

show
hide
Language(s):
 Dates: 2019-032019-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/mrm.27742
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Magnetic Resonance in Medicine
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 82 (2) Sequence Number: - Start / End Page: 527 - 550 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149