English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Topography of a visuomotor transformation

Helmbrecht, T. O., Dal Maschio, M., Donovan, J. C., Koutsouli, S., & Baier, H. (2018). Topography of a visuomotor transformation. Neuron, 100(6), 1429-1445.e4. doi:10.1016/j.neuron.2018.10.021.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Helmbrecht, Thomas O.1, Author              
Dal Maschio, Marco1, Author              
Donovan, Joseph C.1, Author              
Koutsouli, Styliani1, Author              
Baier, Herwig1, Author              
Affiliations:
1Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society, ou_1128545              

Content

show
hide
Free keywords: FUNCTIONAL GROUND PLAN; SUPERIOR COLLICULUS; OPTIC TECTUM; LARVAL ZEBRAFISH; EYE-MOVEMENTS; ELECTRICAL-STIMULATION; OUTPUT PATHWAYS; NEURAL-CONTROL; PREY CAPTURE; RANA-PIPIENSNeurosciences & Neurology;
 Abstract: The brain converts perceptual information into appropriate patterns of muscle activity depending on the categorization and localization of sensory cues. Sensorimotor information might either be encoded by distributed networks or by "labeled lines'' connecting sensory channels to dedicated behavioral pathways. Here we investigate, in the context of natural behavior, how the tectum of larval zebrafish can inform downstream premotor areas. Optogenetic mapping revealed a tectal motor map underlying locomotor maneuvers for escape and approach. Single-cell reconstructions and high-resolution functional imaging showed that two spatially segregated and uncrossed descending axon tracts selectively transmit approach and escape signals to the hindbrain. Moreover, the approach pathway conveys information about retinotopic target coordinates to specific premotor ensembles via spatially ordered axonal projections. This topographic organization supports a tectum-generated space code sufficient to steer orienting movements. We conclude that specific labeled lines guide object-directed behavior in the larval zebrafish brain.

Details

show
hide
Language(s): eng - English
 Dates: 2018
 Publication Status: Published in print
 Pages: 21
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : SFB 870 “Assembly and Function of Neural Circuits”
Grant ID : -
Funding program : -
Funding organization : DFG
Project name : FETNeuram
Grant ID : -
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)

Source 1

show
hide
Title: Neuron
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 100 (6) Sequence Number: - Start / End Page: 1429 - 1445.e4 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565