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  Food and water restriction lead to differential learning behaviors in a head-fixed two-choice visual discrimination task for mice

Goltstein, P. M., Reinert, S., Glas, A., Bonhoeffer, T., & Hübener, M. (2018). Food and water restriction lead to differential learning behaviors in a head-fixed two-choice visual discrimination task for mice. PLoS One, 13(9): e0204066. doi:10.1371/journal.pone.0204066.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-7464-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-7465-9
Genre: Journal Article

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 Creators:
Goltstein, Pieter M.1, Author              
Reinert, Sandra1, Author              
Glas, Annet1, Author              
Bonhoeffer, Tobias1, Author              
Hübener, Mark1, Author              
Affiliations:
1Department: Synapses-Circuits-Plasticity / Bonhoeffer, MPI of Neurobiology, Max Planck Society, ou_1113545              

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Free keywords: CELLULAR RESOLUTION; VIRTUAL-NAVIGATION; NEURAL ACTIVITY; CORTEX; MOUSE; RATS; PARAMETERS; CONTRAST; CIRCUIT; SIGNALSScience & Technology - Other Topics;
 Abstract: Head-fixed behavioral tasks can provide important insights into cognitive processes in rodents. Despite the widespread use of this experimental approach, there is only limited knowledge of how differences in task parameters, such as motivational incentives, affect overall task performance. Here, we provide a detailed methodological description of the setup and procedures for training mice efficiently on a two-choice lick left/lick right visual discrimination task. We characterize the effects of two distinct restriction regimens, i.e. food and water restriction, on animal wellbeing, activity patterns, task acquisition, and performance. While we observed reduced behavioral activity during the period of food and water restriction, the average animal discomfort scores remained in the 'sub-threshold' and 'mild' categories throughout the experiment, irrespective of the restriction regimen. We found that the type of restriction significantly influenced specific aspects of task acquisition and engagement, i.e. the number of sessions until the learning criterion was reached and the number of trials performed per session, but it did not affect maximum learning curve performance. These results indicate that the choice of restriction paradigm does not strongly affect animal wellbeing, but it can have a significant effect on how mice perform in a task.

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Language(s): eng - English
 Dates: 2018
 Publication Status: Published online
 Pages: 19
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 Table of Contents: -
 Rev. Method: Peer
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 13 (9) Sequence Number: e0204066 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850