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  Revisiting the developmental and cellular role of the pigmentation gene yellow in Drosophila using a tagged allele

Hinaux, H., Bachem, K., Battistara, M., Rossi, M., Xin, Y., Jaenichen, R., et al. (2018). Revisiting the developmental and cellular role of the pigmentation gene yellow in Drosophila using a tagged allele. Developmental Biology, 438(2), 111-123. doi:10.1016/j.ydbio.2018.04.003.

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 Creators:
Hinaux, Helene1, Author
Bachem, Katharina1, Author
Battistara, Margherita1, Author
Rossi, Matteo1, Author
Xin, Yaqun1, Author
Jaenichen, Rita1, Author
Le Poul, Yann1, Author
Arnoult, Laurent1, Author
Kobler, Johanna M.2, Author              
Kadow, Ilona C. Grunwald1, Author
Rodermund, Lisa1, Author
Prud'homme, Benjamin1, Author
Gompel, Nicolas1, Author
Affiliations:
1external, ou_persistent22              
2Max Planck Research Group: Chemosensory coding / Grunwald-Kadow, MPI of Neurobiology, Max Planck Society, ou_1113556              

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Free keywords: FLUORESCENT PROTEIN; NERVOUS-SYSTEM; MALE COURTSHIP; MELANOGASTER; EVOLUTION; PATTERNS; CUTICLE; SCLEROTIZATION; MELANIZATION; LOCUSDevelopmental Biology; Pigmentation; Insect; Melanin; Cell trafficking; Live imaging; Pattern boundary;
 Abstract: Pigmentation is a diverse and ecologically relevant trait in insects. Pigment formation has been studied extensively at the genetic and biochemical levels. The temporality of pigment formation during animal development, however, is more elusive. Here, we examine this temporality, focusing on yellow, a gene involved in the formation of black melanin. We generated a protein-tagged yellow allele m the fruit fly Drosophila melanogaster, which allowed us to precisely describe Yellow expression pattern at the tissue and cellular levels throughout development. We found Yellow expressed in the pupal epidermis in patterns prefiguring black pigmentation. We also found Yellow expressed in a few central neurons from the second larval instar to adult stages, including a subset of neurons adjacent to the clock neurons marked by the gene Pdf. We then specifically examined the dynamics of Yellow expression domain and subcellular localization in relationship to pigment formation. In particular, we showed how a late step of re-internalization is regulated by the large low-density lipoprotein receptor-related protein Megalin. Finally we suggest a new function for Yellow in the establishment of sharp pigmentation pattern boundaries, whereby this protein may assume a structural role, anchoring pigment deposits or pigmentation enzymes in the cuticle.

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Language(s): eng - English
 Dates: 2018
 Publication Status: Published in print
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: Developmental Biology
Source Genre: Journal
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Publ. Info: San Diego [etc.] : Academic Press
Pages: - Volume / Issue: 438 (2) Sequence Number: - Start / End Page: 111 - 123 Identifier: ISSN: 0012-1606
CoNE: https://pure.mpg.de/cone/journals/resource/954927680586