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  Non-uniform weighting of local motion inputs underlies dendritic computation in the fly visual system

Dan, O., Hopp, E., Borst, A., & Segev, I. (2018). Non-uniform weighting of local motion inputs underlies dendritic computation in the fly visual system. Scientific Reports, 8: 5787. doi:10.1038/s41598-018-23998-9.

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Dan, Ohad, Author
Hopp, Elisabeth1, Author           
Borst, Alexander1, Author           
Segev, Idan, Author
Affiliations:
1Department: Circuits-Computation-Models / Borst, MPI of Neurobiology, Max Planck Society, ou_1113548              

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Free keywords: RECEPTIVE-FIELD ORGANIZATION; GIANT VERTICAL CELLS; NEURONS IN-VIVO; LOBULA PLATE; SENSITIVE INTERNEURONS; DIRECTION SELECTIVITY; CALCIUM ACCUMULATION; ELECTROTONIC LENGTH; RESPONSE PROPERTIES; BLOWFLY CALLIPHORAScience & Technology - Other Topics;
 Abstract: The fly visual system offers a unique opportunity to explore computations performed by single neurons. Two previous studies characterized, in vivo, the receptive field (RF) of the vertical system (VS) cells of the blowfly (calliphora vicina), both intracellularly in the axon, and, independently using Ca2+ imaging, in hundreds of distal dendritic branchlets. We integrated this information into detailed passive cable and compartmental models of 3D reconstructed VS cells. Within a given VS cell type, the transfer resistance (TR) from different branchlets to the axon differs substantially, suggesting that they contribute unequally to the shaping of the axonal RF. Weighting the local RFs of all dendritic branchlets by their respective TR yielded a faithful reproduction of the axonal RF. The model also predicted that the various dendritic branchlets are electrically decoupled from each other, thus acting as independent local functional subunits. The study suggests that single neurons in the fly visual system filter dendritic noise and compute the weighted average of their inputs.

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Language(s): eng - English
 Dates: 2018-04-10
 Publication Status: Issued
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 8 Sequence Number: 5787 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322