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  Motor context dominates output from purkinje cell functional regions during reflexive visuomotor behaviours

Knogler, L. D., Kist, A. M., & Portugues, R. (2019). Motor context dominates output from purkinje cell functional regions during reflexive visuomotor behaviours. eLife, 8: e42138. doi:10.7554/eLife.42138.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-68BE-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-68BF-2
Genre: Journal Article

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Data availability Example electrophysiological datasets are available at https://zenodo.org/record/1494071. An example imaging dataset is available at https://zenodo.org/record/1638807. MATLAB code for electrophysiological analysis available via GitHub (https://github.com/portugueslab/Knogler_etal_2019_eLife; copy archived athttps://github.com/elifesciences-publications/Knogler_etal_2019_eLife).
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https://elifesciences.org/articles/42138 (Publisher version)
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 Creators:
Knogler, Laura D.1, Author              
Kist, Andreas M.1, Author              
Portugues, Ruben1, Author              
Affiliations:
1Max Planck Research Group: Sensorimotor Control / Portugues, MPI of Neurobiology, Max Planck Society, ou_2054291              

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Free keywords: CLIMBING FIBER INPUT; CEREBELLAR GRANULE CELLS; LARVAL ZEBRAFISH; LOCOMOTOR-ACTIVITY; SPIKE ACTIVITY; NEURONS; REPERTOIRE; MODULATION; REGRESSION; INHIBITIONLife Sciences & Biomedicine - Other Topics;
 Abstract: The cerebellum integrates sensory stimuli and motor actions to enable smooth coordination and motor learning. Here we harness the innate behavioral repertoire of the larval zebrafish to characterize the spatiotemporal dynamics of feature coding across the entire Purkinje cell population during visual stimuli and the reflexive behaviors that they elicit. Population imaging reveals three spatially-clustered regions of Purkinje cell activity along the rostrocaudal axis. Complementary single-cell electrophysiological recordings assign these Purkinje cells to one of three functional phenotypes that encode a specific visual, and not motor, signal via complex spikes. In contrast, simple spike output of most Purkinje cells is strongly driven by motor-related tail and eye signals. Interactions between complex and simple spikes show heterogeneous modulation patterns across different Purkinje cells, which become temporally restricted during swimming episodes. Our findings reveal how sensorimotor information is encoded by individual Purkinje cells and organized into behavioral modules across the entire cerebellum.

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Language(s): eng - English
 Dates: 2019
 Publication Status: Published online
 Pages: 36
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: ISI: 000458604700001
DOI: 10.7554/eLife.42138
 Degree: -

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Grant ID : PO 2105/2–1
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Funding organization : German Research Foundation

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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 8 Sequence Number: e42138 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X