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  Transcriptional control of morphological properties of direction-selective T4/T5 neurons in Drosophila

Schilling, T., Ali, A. H., Leonhardt, A., Borst, A., & Pujol-Marti, J. (2019). Transcriptional control of morphological properties of direction-selective T4/T5 neurons in Drosophila. Development, 146(2): dev169763. doi:10.1242/dev.169763.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-6943-C Version Permalink: http://hdl.handle.net/21.11116/0000-0003-6944-B
Genre: Journal Article

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 Creators:
Schilling, Tabea1, Author              
Ali, Aicha H.1, Author              
Leonhardt, Aljoscha1, Author              
Borst, Alexander1, Author              
Pujol-Marti, Jesus1, Author              
Affiliations:
1Department: Circuits-Computation-Models / Borst, MPI of Neurobiology, Max Planck Society, ou_1113548              

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Free keywords: EDGE MOTION DETECTION; VISUAL INTERNEURONS; LOBULA PLATE; DIFFERENTIATION; PATHWAYS; GENE; EXPRESSION; DIVERSITY; MIGRATION; SOXNEURODevelopmental Biology; Neural development; Layer specificity; Optic lobe; Drosophila; SoxN; Sox102F;
 Abstract: In the Drosophila visual system, T4/T5 neurons represent the first stage of computation of the direction of visual motion. T4 and T5 neurons exist in four subtypes, each responding to motion in one of the four cardinal directions and projecting axons into one of the four lobula plate layers. However, all T4/T5 neurons share properties essential for sensing motion. How T4/T5 neurons acquire their properties during development is poorly understood. We reveal that the transcription factors SoxN and Sox102F control the acquisition of properties common to all T4/T5 neuron subtypes, i.e. the layer specificity of dendrites and axons. Accordingly, adult flies are motion blind after disruption of SoxN or Sox102F in maturing T4/T5 neurons. We further find that the transcription factors Ato and Dac are redundantly required in T4/T5 neuron progenitors for SoxN and Sox102F expression in T4/T5 neurons, linking the transcriptional programmes specifying progenitor identity to those regulating the acquisition of morphological properties in neurons. Our work will help to link structure, function and development in a neuronal type performing a computation that is conserved across vertebrate and invertebrate visual systems.

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Language(s): eng - English
 Dates: 2019-01-14
 Publication Status: Published online
 Pages: 15
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: ISI: 000457418100013
DOI: 10.1242/dev.169763
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Title: Development
  Other : Development
Source Genre: Journal
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Publ. Info: Cambridge, Cambridgeshire : Company of Biologists
Pages: - Volume / Issue: 146 (2) Sequence Number: dev169763 Start / End Page: - Identifier: ISSN: 0950-1991
CoNE: https://pure.mpg.de/cone/journals/resource/954927546241