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  Visual deprivation independent shift of ocular dominance induced by cross-modal plasticity

Teichert, M., Isstas, M., Liebmann, L., Huebner, C. A., Wieske, F., Winter, C., et al. (2019). Visual deprivation independent shift of ocular dominance induced by cross-modal plasticity. PLoS One, 14(3): e0213616. doi:10.1371/journal.pone.0213616.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-6885-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-6886-1
Genre: Journal Article

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 Creators:
Teichert, Manuel1, Author              
Isstas, Marcel2, Author
Liebmann, Lutz2, Author
Huebner, Christian A.2, Author
Wieske, Franziska2, Author
Winter, Christine2, Author
Lehmann, Konrad2, Author
Bolz, Juergen2, Author
Affiliations:
1Department: Synapses-Circuits-Plasticity / Bonhoeffer, MPI of Neurobiology, Max Planck Society, ou_1113545              
2external, ou_persistent22              

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Free keywords: EXPERIENCE-DEPENDENT PLASTICITY; CRITICAL-PERIOD PLASTICITY; CONDUCTIVE HEARING-LOSS; LONG-TERM POTENTIATION; INTRINSIC SIGNAL; ENVIRONMENTAL ENRICHMENT; HOMEOSTATIC PLASTICITY; ADULT; CORTEX; VISIONScience & Technology - Other Topics;
 Abstract: There is convincing evidence that the deprivation of one sense can lead to adaptive neuronal changes in spared primary sensory cortices. However, the repercussions of late-onset sensory deprivations on functionality of the remaining sensory cortices are poorly understood. Using repeated intrinsic signal imaging we investigated the effects of whisker or auditory deprivation (WD or AD, respectively) on responsiveness of the binocular primary visual cortex (V1) in fully adult mice. The binocular zone of mice is innervated by both eyes, with the contralateral eye always dominating V1 input over ipsilateral eye input, the normal ocular dominance (OD) ratio. Strikingly, we found that 3 days of WD or AD induced a transient shift of OD, which was mediated by a potentiation of V1 input through the ipsilateral eye. This cross-modal effect was accompanied by strengthening of layer 4 synapses in V1, required visual experience through the ipsilateral eye and was mediated by an increase of the excitation/inhibition ratio in V1. Finally, we demonstrate that both WD and AD induced a long-lasting improvement of visual performance. Our data provide evidence that the deprivation of a non-visual sensory modality cross-modally induces experience dependent V1 plasticity and improves visual behavior, even in adult mice.

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Language(s): eng - English
 Dates: 2019
 Publication Status: Published online
 Pages: 32
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 14 (3) Sequence Number: e0213616 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850