English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis

Witte, M. E., Schumacher, A.-M., Mahler, C. F., Bewersdorf, J. P., Lehmitz, J., Scheiter, A., et al. (2019). Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis. Neuron, 101(4), 615-624.e5. doi:10.1016/j.neuron.2018.12.023.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0003-68A5-E Version Permalink: http://hdl.handle.net/21.11116/0000-0003-68AA-9
Genre: Journal Article

Files

show Files
hide Files
:
1-s2.0-S0896627318311231-main.pdf (Publisher version), 4MB
Name:
1-s2.0-S0896627318311231-main.pdf
Description:
open access
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
© 2018 The Author(s).
:
1-s2.0-S0896627318311231-mmc2.mp4 (Supplementary material), 3MB
Name:
1-s2.0-S0896627318311231-mmc2.mp4
Description:
-
Visibility:
Public
MIME-Type / Checksum:
video/mp4 / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
1-s2.0-S0896627318311231-mmc1.pdf (Supplementary material), 7MB
Name:
1-s2.0-S0896627318311231-mmc1.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Witte, Maarten E.1, Author
Schumacher, Adrian-Minh1, Author
Mahler, Christoph F.1, Author
Bewersdorf, Jan P.1, Author
Lehmitz, Jonas1, Author
Scheiter, Alexander1, Author
Sanchez, Paula1, Author
Williams, Philip R.1, Author
Griesbeck, Oliver2, Author              
Naumann, Ronald1, Author
Misgeld, Thomas1, Author
Kerschensteiner, Martin1, Author
Affiliations:
1external, ou_persistent22              
2Research Group: Tools for Bio-Imaging / Griesbeck, MPI of Neurobiology, Max Planck Society, ou_1113560              

Content

show
hide
Free keywords: SECONDARY DEGENERATION; CA2+ RELEASE; MECHANISMS; INJURY; DYSFUNCTION; NEURONS; STRESS; DAMAGE; CNSNeurosciences & Neurology;
 Abstract: Axon loss determines persistent disability in multiple sclerosis patients. Here, we use in vivo calcium imaging in a multiple sclerosis model to show that cytoplasmic calcium levels determine the choice between axon loss and survival. We rule out the endoplasmic reticulum, glutamate excitotoxicity, and the reversal of the sodium-calcium exchanger as sources of intra-axonal calcium accumulation and instead identify nanoscale ruptures of the axonal plasma membrane as the critical path of calcium entry.

Details

show
hide
Language(s): eng - English
 Dates: 2019-01-242019-02
 Publication Status: Published in print
 Pages: 15
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Neuron
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 101 (4) Sequence Number: - Start / End Page: 615 - 624.e5 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565