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  Dynamic Glucose Enhanced MRI at Ultra-High Field in Glioblastoma Patients

Paech, D., Köhler, C., Schuenke, P., Zaiss, M., Windschuh, J., Bonekamp, D., et al. (2016). Dynamic Glucose Enhanced MRI at Ultra-High Field in Glioblastoma Patients. Clinical Neuroradiology, 26(Supplement 1): 196, S20.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0003-601A-4 Version Permalink: https://hdl.handle.net/21.11116/0000-0003-601B-3
Genre: Meeting Abstract

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https://link.springer.com/content/pdf/10.1007%2Fs00062-016-0531-2.pdf (Publisher version)
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 Creators:
Paech, D, Author
Köhler, C, Author
Schuenke, P, Author
Zaiss, M1, 2, Author           
Windschuh, J, Author
Bonekamp, D, Author
Bachert, P, Author
Ladd, M, Author
Wick, W, Author
Bendszus, M, Author
Schlemmer, H-P, Author
Radbruch, A, Author
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Purpose: To investigate if a tumor contrast can be obtained in glioblastoma patients at ultra-high field magnetic resonance imaging (MRI) using simple D-glucose as biodegradable contrast agent.
Patients & Methods: 8 newly diagnosed glioblastoma patients were included in this prospective ethic approved study. Adiabatic chemical exchange sensitive spin-lock (CESL) preparation followed by conventional
MRI readout was realized at a 7 Tesla (7 T) whole-body scanner. 100 ml of 20 % D-glucose were injected manually after 4 minutes baseline measurements yielding the 5 second time-resolved dynamic glucose enhanced (DGE) contrast.
Results: No complication after glucose injection was observed in any patient. In all analyzed patients a DGE contrast was obtained that allowed the identification of the tumor and time-resolved visualization
of intratumoral glucose uptake (Fig. 1). Glucose enhanced signal intensity was significantly increased in glioblastoma tumors compared to contralateral normal appearing white matter (p < 0.001).
Discussion: Our investigations in a homogenous glioblastoma patient
collective showed that simple glucose can be used in ultra-high field DGE imaging as biodegradable contrast agent for the visualization of intracranial tumors generating new insights into tumor metabolism.

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 Dates: 2016-09
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1007/s00062-016-0531-2
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Title: 51. Jahrestagung der Deutschen Gesellschaft für Neuroradiologie e.V. in Kooperation mit der 24. Jahrestagung der Österreichischen Gesellschaft für Neuroradiologie
Place of Event: Köln, Germany
Start-/End Date: 2016-10-05 - 2016-10-08

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Title: Clinical Neuroradiology
Source Genre: Journal
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Pages: - Volume / Issue: 26 (Supplement 1) Sequence Number: 196 Start / End Page: S20 Identifier: -