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  Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils

Grassi, L., Pourfarzad, F., Ullrich, S., Merkel, A., Were, F., Carrillo-de-Santa-Pau, E., et al. (2018). Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils. Cell Reports, 24(10), 2784-2794. doi:10.1016/j.celrep.2018.08.018.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-6ED4-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-5AC1-D
Genre: Journal Article

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 Creators:
Grassi, L., Author
Pourfarzad, F., Author
Ullrich, S., Author
Merkel, A., Author
Were, F., Author
Carrillo-de-Santa-Pau, E., Author
Yi, G., Author
Hiemstra, I. H., Author
Tool, A. T. J., Author
Mul, E., Author
Perner, J., Author
Janssen-Megens, E., Author
Berentsen, K., Author
Kerstens, H., Author
Habibi, E., Author
Gut, M., Author
Yaspo, M. L.1, Author              
Linser, M., Author
Lowy, E., Author
Datta, A., Author
Clarke, L., AuthorFlicek, P., AuthorVingron, M.2, Author              Roos, D., Authorvan den Berg, T. K., AuthorHeath, S., AuthorRico, D., AuthorFrontini, M., AuthorKostadima, M., AuthorGut, I., AuthorValencia, A., AuthorOuwehand, W. H., AuthorStunnenberg, H. G., AuthorMartens, J. H. A., AuthorKuijpers, T. W., Author more..
Affiliations:
1Gene Regulation and Systems Biology of Cancer (Marie-Laure Yaspo), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2117287              
2Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479639              

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Free keywords: epigenome myeloid differentiation neutrophil transcriptome
 Abstract: Neutrophils are short-lived blood cells that play a critical role in host defense against infections. To better comprehend neutrophil functions and their regulation, we provide a complete epigenetic overview, assessing important functional features of their differentiation stages from bone marrow-residing progenitors to mature circulating cells. Integration of chromatin modifications, methylation, and transcriptome dynamics reveals an enforced regulation of differentiation, for cellular functions such as release of proteases, respiratory burst, cell cycle regulation, and apoptosis. We observe an early establishment of the cytotoxic capability, while the signaling components that activate these antimicrobial mechanisms are transcribed at later stages, outside the bone marrow, thus preventing toxic effects in the bone marrow niche. Altogether, these data reveal how the developmental dynamics of the chromatin landscape orchestrate the daily production of a large number of neutrophils required for innate host defense and provide a comprehensive overview of differentiating human neutrophils.

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Language(s): eng - English
 Dates: 2018-09-04
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: Other: 30184510
DOI: 10.1016/j.celrep.2018.08.018
ISSN: 2211-1247 (Electronic)
 Degree: -

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Title: Cell Reports
Source Genre: Journal
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Publ. Info: Maryland Heights, MO : Cell Press
Pages: - Volume / Issue: 24 (10) Sequence Number: - Start / End Page: 2784 - 2794 Identifier: ISSN: 2211-1247
CoNE: https://pure.mpg.de/cone/journals/resource/2211-1247