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  Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes

Pulit, S. L., Weng, L.-C., McArdle, P. F., Trinquart, L., Choi, S. H., Mitchell, B. D., Rosand, J., de Bakker, P. I. W., Benjamin, E. J., Ellinor, P. T., Kittner, S. J., Lubitz, S. A., Anderson, C. D., Christophersen, I. E., Rienstra, M., Roselli, C., Yin, X., Geelhoed, B., Barnard, J., Lin, H., Arking, D. E., Smith V, A., Albert, C. M., Chaffin, M., Tucker, N. R., Li, M., Klarin, D., Bihlmeyer, N. A., Low, S.-K., Weeke, P. E., Mueller-Nurasyid, M., Smith, J. G., Brody, J. A., Niemeijer, M. N., Doerr, M., Trompet, S., Huffman, J., Gustafsson, S., Schurmann, C., Kleber, M. E., Lyytikainen, L.-P., Seppala, I., Malik, R., Horimoto, A. R. V. R., Perez, M., Sinisalo, J., Aeschbacher, S., Theriault, S., Yao, J., Radmanesh, F., Weiss, S., Teumer, A., Clauss, S., Deo, R., Rader, D. J., Shah, S., Sun, A., Hopewell, J. C., Debette, S., Chauhan, G., Yang, Q., Worrall, B. B., Pare, G., Kamatani, Y., Hagemeijer, Y. P., Verweij, N., Siland, J. E., Kubo, M., Smith, J. D., Van Wagoner, D. R., Bis, J. C., Perz, S., Psaty, B. M., Ridker, P. M., Magnani, J. W., Harris, T. B., Launer, L. J., Shoemaker, M. B., Padmanabhan, S., Haessler, J., Bartz, T. M., Waldenberger, M., Lichtner, P., Arendt, M., Krieger, J. E., Kahonen, M., Risch, L., Mansur, A. J., Peters, A., Smith, B. H., Lind, L., Scott, S. A., Lu, Y., Bottinger, E. B., Hernesniemi, J., Lindgren, C. M., Wong, J. A., Huang, J., Eskola, M., Morris, A. P., Ford, I., Reiner, A. P., Delgado, G., Chen, L. Y., Chen, Y.-D.-I., Sandhu, R. K., Li, M., Boerwinkle, E., Eisele, L., Lannfelt, L., Rost, N., Taylor, K. D., Campbell, A., Magnusson, P. K., Porteous, D., Hocking, L. J., Vlachopoulou, E., Pedersen, N. L., Nikus, K., Orho-Melander, M., Hamsten, A., Heeringa, J., Denny, J. C., Kriebel, J., Darbar, D., Newton-Cheh, C., Shaffer, C., Macfarlane, P. W., Heilmann, S., Almgren, P., Huang, P. L., Sotoodehnia, N., Soliman, E. Z., Uitterlinden, A. G., Hofman, A., Franco, O. H., Voelker, U., Joeckel, K.-H., Sinner, M. F., Lin, H. J., Guo, X., Dichgans, M., Ingelsson, E., Kooperberg, C., Melander, O., Loos, R. J. F., Laurikka, J., Conen, D., van der Harst, P., Lokki, M.-L., Kathiresan, S., Pereira, A., Jukema, J. W., Hayward, C., Rotter I, J., Maerz, W., Lehtimaki, T., Stricker, B. H., Chung, M. K., Felix, S. B., Gudnason, V., Alonso, A., Roden, D. M., Kaeaeb, S., Chasman I, D., Heckbert, S. R., Tanaka, T., Lunetta, K. L., Smoller, S., Sorkin, J., Wang, X., Selim, M., Pikula, A., Wolf, P., Seshadri, S., de Bakker, P., Chasman, D., Rexrode, K., Chen, I., Rotter, J., Luke, M., Sale, M., Lee, T.-H., Chang, K.-C., Elkind, M., Goldstein, L., James, M. L., Breteler, M., O'Donnell, C., Leys, D., Carty, C., Kidwell, C., Olesen, J., Sharma, P., Rich, S., Tatlisumak, T., Happola, O., Bijlenga, P., Soriano, C., Giralt, E., Roquer, J., Jimenez-Conde, J., Cotlarcius, I., Hardy, J., Korostynski, M., Boncoraglio, G., Ballabio, E., Parati, E., Mateusz, A., Urbanik, A., Dziedzic, T., Jagiella, J., Gasowski, J., Wnuk, M., Olszanecki, R., Pera, J., Slowik, A., Juchniewicz, K. J., Levi, C., Nyquist, P., Cendes, I., Cabral, N., Franca, P., Goncalves, A., Keller, L., Crisby, M., Kostulas, K., Lemmens, R., Ahmadi, K., Opherk, C., Duering, M., Gonik, M., Staals, J., Burri, P., Sadr-Nabavi, A., Romero, J., Biffi, A., Anderson, C., Falcone, G., Brouwers, B., Du, R., Kourkoulis, C., Battey, T., Lubitz, S., Mueller-Myhsok, B., Meschia, J., Brott, T., Pichler, A., Enzinger, C., Schmidt, H., Schmidt, R., Seiler, S., Blanton, S., Yamada, Y., Bersano, A., Rundek, T., Sacco, R., Chan, Y.-F.-Y., Gschwendtner, A., Deng, Z., Barr, T., Gwinn, K., Corriveau, R., Singleton, A., Waddy, S., Launer, L., Chen, C., Le, K. E., Lee, W. L., Tan, E. K., Olugbodi, A., Rothwell, P., Schilling, S., Mok, V., Lebedeva, E., Jern, C., Jood, K., Olsson, S., Kim, H., Lee, C., Kilarski, L., Markus, H., Peycke, J., Bevan, S., Sheu, W., Chiou, H. Y., Chern, J., Giraldo, E., Taqi, M., Jain, V., Lam, O., Howard, G., Woo, D., Kittner, S., Mitchell, B., Cole, J., O'Connell, J., Milewicz, D., Illoh, K., Worrall, B., Stine, C., Karaszewski, B., Werring, D., Sofat, R., Smalley, J., Lindgren, A., Hansen, B., Norrving, B., Smith, G., Jose Martin, J., Thijs, V., Klijn, K., van't Hof, F., Algra, A., Macleod, M., Perry, R., Arnett, D., Pezzini, A., Padovani, A., Cramer, S., Fisher, M., Saleheen, D., Broderick, J., Kissela, B., Doney, A., Sudlow, C., Rannikmae, K., Silliman, S., McDonough, C., Walters, M., Pedersen, A., Nakagawa, K., Chang, C., Dobbins, M., McArdle, P., Chang, Y.-C., Brown, R., Brown, D., Holliday, E., Kalaria, R., Maguire, J., Attia, J., Farrall, M., Giese, A.-K., Fornage, M., Majersik, J., Cushman, M., Keene, K., Bennett, S., Tirschwell, D., Psaty, B., Reiner, A., Longstreth, W., Spence, D., Montaner, J., Fernandez-Cadenas, I., Langefeld, C., Bushnell, C., Heitsch, L., Lee, J.-M., & Sheth, K. (2018). Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes. NEUROLOGY GENETICS, 4(6):. doi:10.1212/NXG.0000000000000293.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0003-9171-9 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0003-9172-8
資料種別: 学術論文

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e293.full.pdf
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 作成者:
Pulit, Sara L.1, 著者
Weng, Lu-Chen1, 著者
McArdle, Patrick F.1, 著者
Trinquart, Ludovic1, 著者
Choi, Seung Hoan1, 著者
Mitchell, Braxton D.1, 著者
Rosand, Jonathan1, 著者
de Bakker, Paul I. W.1, 著者
Benjamin, Emelia J.1, 著者
Ellinor, Patrick T.1, 著者
Kittner, Steven J.1, 著者
Lubitz, Steven A.1, 著者
Anderson, Christopher D.1, 著者
Christophersen, Ingrid E.1, 著者
Rienstra, Michiel1, 著者
Roselli, Carolina1, 著者
Yin, Xiaoyan1, 著者
Geelhoed, Bastiaan1, 著者
Barnard, John1, 著者
Lin, Honghuang1, 著者
Arking, Dan E.1, 著者Smith V, Albert1, 著者Albert, Christine M.1, 著者Chaffin, Mark1, 著者Tucker, Nathan R.1, 著者Li, Molong1, 著者Klarin, Derek1, 著者Bihlmeyer, Nathan A.1, 著者Low, Siew-Kee1, 著者Weeke, Peter E.1, 著者Mueller-Nurasyid, Martina1, 著者Smith, J. Gustav1, 著者Brody, Jennifer A.1, 著者Niemeijer, Maartje N.1, 著者Doerr, Marcus1, 著者Trompet, Stella1, 著者Huffman, Jennifer1, 著者Gustafsson, Stefan1, 著者Schurmann, Claudia1, 著者Kleber, Marcus E.1, 著者Lyytikainen, Leo-Pekka1, 著者Seppala, Ilkka1, 著者Malik, Rainer1, 著者Horimoto, Andrea R. V. R.1, 著者Perez, Marco1, 著者Sinisalo, Juha1, 著者Aeschbacher, Stefanie1, 著者Theriault, Sebastien1, 著者Yao, Jie1, 著者Radmanesh, Farid1, 著者Weiss, Stefan1, 著者Teumer, Alexander1, 著者Clauss, Sebastian1, 著者Deo, Rajat1, 著者Rader, Daniel J.1, 著者Shah, Svati1, 著者Sun, Albert1, 著者Hopewell, Jemma C.1, 著者Debette, Stephanie1, 著者Chauhan, Ganesh1, 著者Yang, Qiong1, 著者Worrall, Bradford B.1, 著者Pare, Guillaume1, 著者Kamatani, Yoichiro1, 著者Hagemeijer, Yanick P.1, 著者Verweij, Niek1, 著者Siland, Joylene E.1, 著者Kubo, Michiaki1, 著者Smith, Jonathan D.1, 著者Van Wagoner, David R.1, 著者Bis, Joshua C.1, 著者Perz, Siegfried1, 著者Psaty, Bruce M.1, 著者Ridker, Paul M.1, 著者Magnani, Jared W.1, 著者Harris, Tamara B.1, 著者Launer, Lenore J.1, 著者Shoemaker, M. Benjamin1, 著者Padmanabhan, Sandosh1, 著者Haessler, Jeffrey1, 著者Bartz, Traci M.1, 著者Waldenberger, Melanie1, 著者Lichtner, Peter1, 著者Arendt, Marina1, 著者Krieger, Jose E.1, 著者Kahonen, Mika1, 著者Risch, Lorenz1, 著者Mansur, Alfredo J.1, 著者Peters, Annette1, 著者Smith, Blair H.1, 著者Lind, Lars1, 著者Scott, Stuart A.1, 著者Lu, Yingchang1, 著者Bottinger, Erwin B.1, 著者Hernesniemi, Jussi1, 著者Lindgren, Cecilia M.1, 著者Wong, Jorge A.1, 著者Huang, Jie1, 著者Eskola, Markku1, 著者Morris, Andrew P.1, 著者Ford, Ian1, 著者Reiner, Alex P.1, 著者Delgado, Graciela1, 著者Chen, Lin Y.1, 著者Chen, Yii-Der Ida1, 著者Sandhu, Roopinder K.1, 著者Li, Man1, 著者Boerwinkle, Eric1, 著者Eisele, Lewin1, 著者Lannfelt, Lars1, 著者Rost, Natalia1, 著者Taylor, Kent D.1, 著者Campbell, Archie1, 著者Magnusson, Patrik K.1, 著者Porteous, David1, 著者Hocking, Lynne J.1, 著者Vlachopoulou, Efthymia1, 著者Pedersen, Nancy L.1, 著者Nikus, Kjell1, 著者Orho-Melander, Marju1, 著者Hamsten, Anders1, 著者Heeringa, Jan1, 著者Denny, Joshua C.1, 著者Kriebel, Jennifer1, 著者Darbar, Dawood1, 著者Newton-Cheh, Christopher1, 著者Shaffer, Christian1, 著者Macfarlane, Peter W.1, 著者Heilmann, Stefanie1, 著者Almgren, Peter1, 著者Huang, Paul L.1, 著者Sotoodehnia, Nona1, 著者Soliman, Elsayed Z.1, 著者Uitterlinden, Andre G.1, 著者Hofman, Albert1, 著者Franco, Oscar H.1, 著者Voelker, Uwe1, 著者Joeckel, Karl-Heinz1, 著者Sinner, Moritz F.1, 著者Lin, Henry J.1, 著者Guo, Xiuqing1, 著者Dichgans, Martin1, 著者Ingelsson, Erik1, 著者Kooperberg, Charles1, 著者Melander, Olle1, 著者Loos, Ruth J. F.1, 著者Laurikka, Jari1, 著者Conen, David1, 著者van der Harst, Pim1, 著者Lokki, Marja-Liisa1, 著者Kathiresan, Sekar1, 著者Pereira, Alexandre1, 著者Jukema, J. Wouter1, 著者Hayward, Caroline1, 著者Rotter I, Jerome1, 著者Maerz, Winfried1, 著者Lehtimaki, Terho1, 著者Stricker, Bruno H.1, 著者Chung, Mina K.1, 著者Felix, Stephan B.1, 著者Gudnason, Vilmundur1, 著者Alonso, Alvaro1, 著者Roden, Dan M.1, 著者Kaeaeb, Stefan1, 著者Chasman I, Daniel1, 著者Heckbert, Susan R.1, 著者Tanaka, Toshihiro1, 著者Lunetta, Kathryn L.1, 著者Smoller, Sylvia1, 著者Sorkin, John1, 著者Wang, Xingwu1, 著者Selim, Magdy1, 著者Pikula, Aleksandra1, 著者Wolf, Philip1, 著者Seshadri, Sudha1, 著者de Bakker, Paul1, 著者Chasman, Daniel1, 著者Rexrode, Kathryn1, 著者Chen, Ida1, 著者Rotter, Jerome1, 著者Luke, May1, 著者Sale, Michelle1, 著者Lee, Tsong-Hai1, 著者Chang, Ku-Chou1, 著者Elkind, Mitchell1, 著者Goldstein, Larry1, 著者James, Michael Luke1, 著者Breteler, Monique1, 著者O'Donnell, Chris1, 著者Leys, Didier1, 著者Carty, Cara1, 著者Kidwell, Chelsea1, 著者Olesen, Jes1, 著者Sharma, Pankaj1, 著者Rich, Stephen1, 著者Tatlisumak, Turgot1, 著者Happola, Olli1, 著者Bijlenga, Philippe1, 著者Soriano, Carolina1, 著者Giralt, Eva1, 著者Roquer, Jaume1, 著者Jimenez-Conde, Jordi1, 著者Cotlarcius, Ioana1, 著者Hardy, John1, 著者Korostynski, Michal1, 著者Boncoraglio, Giorgio1, 著者Ballabio, Elena1, 著者Parati, Eugenio1, 著者Mateusz, Adamski1, 著者Urbanik, Andrzej1, 著者Dziedzic, Tomasz1, 著者Jagiella, Jeremiasz1, 著者Gasowski, Jerzy1, 著者Wnuk, Marcin1, 著者Olszanecki, Rafael1, 著者Pera, Joanna1, 著者Slowik, Agnieszka1, 著者Juchniewicz, Karol Jozef1, 著者Levi, Christopher1, 著者Nyquist, Paul1, 著者Cendes, Iscia1, 著者Cabral, Norberto1, 著者Franca, Paulo1, 著者Goncalves, Anderson1, 著者Keller, Lina1, 著者Crisby, Milita1, 著者Kostulas, Konstantinos1, 著者Lemmens, Robin1, 著者Ahmadi, Kourosh1, 著者Opherk, Christian1, 著者Duering, Marco1, 著者Gonik, Mariya1, 著者Staals, Julie1, 著者Burri, Philippe1, 著者Sadr-Nabavi, Ariane1, 著者Romero, Javier1, 著者Biffi, Alessandro1, 著者Anderson, Chris1, 著者Falcone, Guido1, 著者Brouwers, Bart1, 著者Du, Rose1, 著者Kourkoulis, Christina1, 著者Battey, Thomas1, 著者Lubitz, Steven1, 著者Mueller-Myhsok, Bertram2, 著者           Meschia, James3, 著者           Brott, Thomas1, 著者Pichler, Alexander1, 著者Enzinger, Christian1, 著者Schmidt, Helena1, 著者Schmidt, Reinhold1, 著者Seiler, Stephan1, 著者Blanton, Susan1, 著者Yamada, Yoshiji1, 著者Bersano, Anna1, 著者Rundek, Tatjana1, 著者Sacco, Ralph1, 著者Chan, Yu-Feng Yvonne1, 著者Gschwendtner, Andreas1, 著者Deng, Zhen1, 著者Barr, Taura1, 著者Gwinn, Katrina1, 著者Corriveau, Roderick1, 著者Singleton, Andrew1, 著者Waddy, Salina1, 著者Launer, Lenore1, 著者Chen, Christopher1, 著者Le, Kim En1, 著者Lee, Wei Ling1, 著者Tan, Eng King1, 著者Olugbodi, Akintomi1, 著者Rothwell, Peter1, 著者Schilling, Sabrina1, 著者Mok, Vincent1, 著者Lebedeva, Elena1, 著者Jern, Christina1, 著者Jood, Katarina1, 著者Olsson, Sandra1, 著者Kim, Helen1, 著者Lee, Chaeyoung1, 著者Kilarski, Laura1, 著者Markus, Hugh1, 著者Peycke, Jennifer1, 著者Bevan, Steve1, 著者Sheu, Wayne1, 著者Chiou, Hung Yi1, 著者Chern, Joseph1, 著者Giraldo, Elias1, 著者Taqi, Muhammad1, 著者Jain, Vivek1, 著者Lam, Olivia1, 著者Howard, George1, 著者Woo, Daniel1, 著者Kittner, Steven1, 著者Mitchell, Braxton1, 著者Cole, John1, 著者O'Connell, Jeff1, 著者Milewicz, Dianna1, 著者Illoh, Kachikwu1, 著者Worrall, Bradford1, 著者Stine, Colin1, 著者Karaszewski, Bartosz1, 著者Werring, David1, 著者Sofat, Reecha1, 著者Smalley, June1, 著者Lindgren, Arne1, 著者Hansen, Bjorn1, 著者Norrving, Bo1, 著者Smith, Gustav1, 著者Jose Martin, Juan1, 著者Thijs, Vincent1, 著者Klijn, Karin1, 著者van't Hof, Femke1, 著者Algra, Ale1, 著者Macleod, Mary1, 著者Perry, Rodney1, 著者Arnett, Donna1, 著者Pezzini, Alessandro1, 著者Padovani, Alessandro1, 著者Cramer, Steve1, 著者Fisher, Mark1, 著者Saleheen, Danish1, 著者Broderick, Joseph1, 著者Kissela, Brett1, 著者Doney, Alex1, 著者Sudlow, Cathie1, 著者Rannikmae, Kristiina1, 著者Silliman, Scott1, 著者McDonough, Caitrin1, 著者Walters, Matthew1, 著者Pedersen, Annie1, 著者Nakagawa, Kazuma1, 著者Chang, Christy1, 著者Dobbins, Mark1, 著者McArdle, Patrick1, 著者Chang, Yu-Ching1, 著者Brown, Robert1, 著者Brown, Devin1, 著者Holliday, Elizabeth1, 著者Kalaria, Raj1, 著者Maguire, Jane1, 著者Attia, John1, 著者Farrall, Martin1, 著者Giese, Anne-Katrin1, 著者Fornage, Myriam1, 著者Majersik, Jennifer1, 著者Cushman, Mary1, 著者Keene, Keith1, 著者Bennett, Siiri1, 著者Tirschwell, David1, 著者Psaty, Bruce1, 著者Reiner, Alex1, 著者Longstreth, Will1, 著者Spence, David1, 著者Montaner, Joan1, 著者Fernandez-Cadenas, Israel1, 著者Langefeld, Carl1, 著者Bushnell, Cheryl1, 著者Heitsch, Laura1, 著者Lee, Jin-Moo1, 著者Sheth, Kevin1, 著者 全て表示
所属:
1External Organizations, ou_persistent22              
2RG Statistical Genetics, Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2040288              
3Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

内容説明

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キーワード: ISCHEMIC-STROKE; CAUSATIVE CLASSIFICATION; LIFETIME RISK; EPIDEMIOLOGY; ASSOCIATION; PREVENTION; VARIANTS; ASPIRIN; BURDENNeurosciences & Neurology;
 要旨: Objective
We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk.
Methods
We evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors.
Results
We observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with p < 4.4 x 10(-4) in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio [OR] per SD = 1.40, p = 1.45 x 10(-48)), explaining similar to 20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07,p = 0.004), but no other primary stroke subtypes (all p > 0.1).
Conclusions
Genetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.

資料詳細

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言語: eng - English
 日付: 2018
 出版の状態: オンラインで出版済み
 ページ: 8
 出版情報: -
 目次: -
 査読: -
 識別子（DOI, ISBNなど）: ISI: 000455099800017
DOI: 10.1212/NXG.0000000000000293
 学位: -

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出版物 1

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出版物名: NEUROLOGY GENETICS
種別: 学術雑誌
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所属:
出版社, 出版地: TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA : LIPPINCOTT WILLIAMS & WILKINS
ページ: - 巻号: 4 (6) 通巻号: e293 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 2376-7839