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  Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Walters, R. K., Polimanti, R., Johnson, E. C., McClintick, J. N., Adams, M. J., Adkins, A. E., et al. (2018). Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. NATURE NEUROSCIENCE, 21(12), 1656-1669. doi:10.1038/s41593-018-0275-1.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0003-8FE9-6 Version Permalink: https://hdl.handle.net/21.11116/0000-0003-8FEA-5
Genre: Journal Article

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 Creators:
Walters, Raymond K.1, Author
Polimanti, Renato1, Author
Johnson, Emma C.1, Author
McClintick, Jeanette N.1, Author
Adams, Mark J.1, Author
Adkins, Amy E.1, Author
Aliev, Fazil1, Author
Bacanu, Silviu-Alin1, Author
Batzler, Anthony1, Author
Bertelsen, Sarah1, Author
Biernacka, Joanna M.1, Author
Bigdeli, Tim B.1, Author
Chen, Li-Shiun1, Author
Clarke, Toni-Kim1, Author
Chou, Yi-Ling1, Author
Degenhardt, Franziska1, Author
Docherty, Anna R.1, Author
Edwards, Alexis C.1, Author
Fontanillas, Pierre1, Author
Foo, Jerome C.1, Author
Fox, Louis1, AuthorFrank, Josef1, AuthorGiegling, Ina1, AuthorGordon, Scott1, AuthorHack, Laura M.1, AuthorHartmann, Annette M.1, AuthorHartz, Sarah M.1, AuthorHeilmann-Heimbach, Stefanie1, AuthorHerms, Stefan1, AuthorHodgkinson, Colin1, AuthorHoffmann, Per1, AuthorHottenga, Jouke Jan1, AuthorKennedy, Martin A.1, AuthorAlanne-Kinnunen, Mervi1, AuthorKonte, Bettina1, AuthorLahti, Jari1, AuthorLahti-Pulkkinen, Marius1, AuthorLai, Dongbing1, AuthorLigthart, Lannie1, AuthorLoukola, Anu1, AuthorMaher, Brion S.1, AuthorMbarek, Hamdi1, AuthorMcIntosh, Andrew M.1, AuthorMcQueen, Matthew B.1, AuthorMeyers, Jacquelyn L.1, AuthorMilaneschi, Yuri1, AuthorPalviainen, Teemu1, AuthorPearson, John F.1, AuthorPeterson, Roseann E.1, AuthorRipatti, Samuli1, AuthorRyu, Euijung1, AuthorSaccone, Nancy L.1, AuthorSalvatore, Jessica E.1, AuthorSanchez-Roige, Sandra1, AuthorSchwandt, Melanie1, AuthorSherva, Richard1, AuthorStreit, Fabian1, AuthorStrohmaier, Jana1, AuthorThomas, Nathaniel1, AuthorWang, Jen-Chyong1, AuthorWebb, Bradley T.1, AuthorWedow, Robbee1, AuthorWetherill, Leah1, AuthorWills, Amanda G.1, AuthorBoardman, Jason D.1, AuthorChen, Danfeng1, AuthorChoi, Doo-Sup1, AuthorCopeland, William E.1, AuthorCulverhouse, Robert C.1, AuthorDahmen, Norbert1, AuthorDegenhardt, Louisa1, AuthorDomingue, Benjamin W.1, AuthorElson, Sarah L.1, AuthorFrye, Mark A.1, AuthorGaebel, Wolfgang1, AuthorHayward, Caroline1, AuthorIsing, Marcus2, Author           Keyes, Margaret1, AuthorKiefer, Falk1, AuthorKramer, John1, AuthorKuperman, Samuel1, AuthorLucae, Susanne2, Author           Lynskey, Michael T.1, AuthorMaier, Wolfgang1, AuthorMann, Karl1, AuthorMannisto, Satu1, AuthorMüller-Myhsok, Bertram3, Author           Murray, Alison D.1, AuthorNurnberger, John I.1, AuthorPalotie, Aarno1, AuthorPreuss, Ulrich1, AuthorRaikkonen, Katri1, AuthorReynolds, Maureen D.1, AuthorRidinger, Monika1, AuthorScherbaum, Norbert1, AuthorSchuckit, Marc A.1, AuthorSoyka, Michael1, AuthorTreutlein, Jens1, AuthorWitt, Stephanie1, AuthorWodarz, Norbert1, AuthorZill, Peter1, AuthorAdkins, Daniel E.1, AuthorBoden, Joseph M.1, AuthorBoomsma, Dorret I.1, AuthorBierut, Laura J.1, AuthorBrown, Sandra A.1, AuthorBucholz, Kathleen K.1, AuthorCichon, Sven1, AuthorCostello, E. Jane1, AuthorDe Wit, Harriet1, AuthorDiazgranados, Nancy1, AuthorDick, Danielle M.1, AuthorEriksson, Johan G.1, AuthorFarrer, Lindsay A.1, AuthorForoud, Tatiana M.1, AuthorGillespie, Nathan A.1, AuthorGoate, Alison M.1, AuthorGoldman, David1, AuthorGrucza, Richard A.1, AuthorHancock, Dana B.1, AuthorHarris, Kathleen Mullan1, AuthorHeath, Andrew C.1, AuthorHesselbrock, Victor1, AuthorHewitt, John K.1, AuthorHopfer, Christian J.1, AuthorHorwood, John1, AuthorIacono, William1, AuthorJohnson, Eric O.1, AuthorKaprio, Jaakko A.1, AuthorKarpyak, Victor M.1, AuthorKendler, Kenneth S.1, AuthorKranzler, Henry R.1, AuthorKrauter, Kenneth1, AuthorLichtenstein, Paul1, AuthorLind, Penelope A.1, AuthorMcGue, Matt1, AuthorMacKillop, James1, AuthorMadden, Pamela A. F.1, AuthorMaes, Hermine H.1, AuthorMagnusson, Patrik1, AuthorMartin, Nicholas G.1, AuthorMedland, Sarah E.1, AuthorMontgomery, Grant W.1, AuthorNelson, Elliot C.1, AuthorNoethen, Markus M.1, AuthorPalmer, Abraham A.1, AuthorPedersen, Nancy L.1, AuthorPenninx, Brenda W. J. H.1, AuthorPorjesz, Bernice1, AuthorRice, John P.1, AuthorRietschel, Marcella1, AuthorRiley, Brien P.1, AuthorRose, Richard1, AuthorRujescu, Dan1, AuthorShen, Pei-Hong1, AuthorSilberg, Judy1, AuthorStallings, Michael C.1, AuthorTarter, Ralph E.1, AuthorVanyukov, Michael M.1, AuthorVrieze, Scott1, AuthorWall, Tamara L.1, AuthorWhitfield, John B.1, AuthorZhao, Hongyu1, AuthorNeale, Benjamin M.1, AuthorGelernter, Joel1, AuthorEdenberg, Howard J.1, AuthorAgrawal, Arpana1, Author more..
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              
3RG Statistical Genetics, Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2040288              

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Free keywords: GENOME-WIDE ASSOCIATION; NATIONAL EPIDEMIOLOGIC SURVEY; LD SCORE REGRESSION; RISK; METAANALYSIS; HERITABILITY; CONSUMPTION; ADH1B; PARTICIPANTS; COMORBIDITYNeurosciences & Neurology;
 Abstract: Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest genome-wide association study to date of DSM-IV-diagnosed AD. Genome-wide data on 14,904 individuals with AD and 37,944 controls from 28 case-control and family-based studies were meta-analyzed, stratified by genetic ancestry (European, n = 46,568; African, n = 6,280). Independent, genome-wide significant effects of different ADH1B variants were identified in European (rs1229984; P = 9.8 x 10(-13)) and African ancestries (rs2066702; P = 2.2 x 10(-9)). Significant genetic correlations were observed with 17 phenotypes, including schizophrenia, attention deficit-hyperactivity disorder, depression, and use of cigarettes and cannabis. The genetic underpinnings of AD only partially overlap with those for alcohol consumption, underscoring the genetic distinction between pathological and nonpathological drinking behaviors.

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Language(s): eng - English
 Dates: 2018
 Publication Status: Issued
 Pages: 16
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000451324700005
DOI: 10.1038/s41593-018-0275-1
 Degree: -

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Title: NATURE NEUROSCIENCE
Source Genre: Journal
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Publ. Info: 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA : NATURE PUBLISHING GROUP
Pages: - Volume / Issue: 21 (12) Sequence Number: - Start / End Page: 1656 - 1669 Identifier: ISSN: 1097-6256