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  Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Walters, R. K., Polimanti, R., Johnson, E. C., McClintick, J. N., Adams, M. J., Adkins, A. E., Aliev, F., Bacanu, S.-A., Batzler, A., Bertelsen, S., Biernacka, J. M., Bigdeli, T. B., Chen, L.-S., Clarke, T.-K., Chou, Y.-L., Degenhardt, F., Docherty, A. R., Edwards, A. C., Fontanillas, P., Foo, J. C., Fox, L., Frank, J., Giegling, I., Gordon, S., Hack, L. M., Hartmann, A. M., Hartz, S. M., Heilmann-Heimbach, S., Herms, S., Hodgkinson, C., Hoffmann, P., Hottenga, J. J., Kennedy, M. A., Alanne-Kinnunen, M., Konte, B., Lahti, J., Lahti-Pulkkinen, M., Lai, D., Ligthart, L., Loukola, A., Maher, B. S., Mbarek, H., McIntosh, A. M., McQueen, M. B., Meyers, J. L., Milaneschi, Y., Palviainen, T., Pearson, J. F., Peterson, R. E., Ripatti, S., Ryu, E., Saccone, N. L., Salvatore, J. E., Sanchez-Roige, S., Schwandt, M., Sherva, R., Streit, F., Strohmaier, J., Thomas, N., Wang, J.-C., Webb, B. T., Wedow, R., Wetherill, L., Wills, A. G., Boardman, J. D., Chen, D., Choi, D.-S., Copeland, W. E., Culverhouse, R. C., Dahmen, N., Degenhardt, L., Domingue, B. W., Elson, S. L., Frye, M. A., Gaebel, W., Hayward, C., Ising, M., Keyes, M., Kiefer, F., Kramer, J., Kuperman, S., Lucae, S., Lynskey, M. T., Maier, W., Mann, K., Mannisto, S., Müller-Myhsok, B., Murray, A. D., Nurnberger, J. I., Palotie, A., Preuss, U., Raikkonen, K., Reynolds, M. D., Ridinger, M., Scherbaum, N., Schuckit, M. A., Soyka, M., Treutlein, J., Witt, S., Wodarz, N., Zill, P., Adkins, D. E., Boden, J. M., Boomsma, D. I., Bierut, L. J., Brown, S. A., Bucholz, K. K., Cichon, S., Costello, E. J., De Wit, H., Diazgranados, N., Dick, D. M., Eriksson, J. G., Farrer, L. A., Foroud, T. M., Gillespie, N. A., Goate, A. M., Goldman, D., Grucza, R. A., Hancock, D. B., Harris, K. M., Heath, A. C., Hesselbrock, V., Hewitt, J. K., Hopfer, C. J., Horwood, J., Iacono, W., Johnson, E. O., Kaprio, J. A., Karpyak, V. M., Kendler, K. S., Kranzler, H. R., Krauter, K., Lichtenstein, P., Lind, P. A., McGue, M., MacKillop, J., Madden, P. A. F., Maes, H. H., Magnusson, P., Martin, N. G., Medland, S. E., Montgomery, G. W., Nelson, E. C., Noethen, M. M., Palmer, A. A., Pedersen, N. L., Penninx, B. W. J. H., Porjesz, B., Rice, J. P., Rietschel, M., Riley, B. P., Rose, R., Rujescu, D., Shen, P.-H., Silberg, J., Stallings, M. C., Tarter, R. E., Vanyukov, M. M., Vrieze, S., Wall, T. L., Whitfield, J. B., Zhao, H., Neale, B. M., Gelernter, J., Edenberg, H. J., & Agrawal, A. (2018). Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. NATURE NEUROSCIENCE, 21(12), 1656-1669. doi:10.1038/s41593-018-0275-1.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0003-8FE9-6 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0003-8FEA-5
資料種別: 学術論文

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作成者

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 作成者:
Walters, Raymond K.1, 著者
Polimanti, Renato1, 著者
Johnson, Emma C.1, 著者
McClintick, Jeanette N.1, 著者
Adams, Mark J.1, 著者
Adkins, Amy E.1, 著者
Aliev, Fazil1, 著者
Bacanu, Silviu-Alin1, 著者
Batzler, Anthony1, 著者
Bertelsen, Sarah1, 著者
Biernacka, Joanna M.1, 著者
Bigdeli, Tim B.1, 著者
Chen, Li-Shiun1, 著者
Clarke, Toni-Kim1, 著者
Chou, Yi-Ling1, 著者
Degenhardt, Franziska1, 著者
Docherty, Anna R.1, 著者
Edwards, Alexis C.1, 著者
Fontanillas, Pierre1, 著者
Foo, Jerome C.1, 著者
Fox, Louis1, 著者Frank, Josef1, 著者Giegling, Ina1, 著者Gordon, Scott1, 著者Hack, Laura M.1, 著者Hartmann, Annette M.1, 著者Hartz, Sarah M.1, 著者Heilmann-Heimbach, Stefanie1, 著者Herms, Stefan1, 著者Hodgkinson, Colin1, 著者Hoffmann, Per1, 著者Hottenga, Jouke Jan1, 著者Kennedy, Martin A.1, 著者Alanne-Kinnunen, Mervi1, 著者Konte, Bettina1, 著者Lahti, Jari1, 著者Lahti-Pulkkinen, Marius1, 著者Lai, Dongbing1, 著者Ligthart, Lannie1, 著者Loukola, Anu1, 著者Maher, Brion S.1, 著者Mbarek, Hamdi1, 著者McIntosh, Andrew M.1, 著者McQueen, Matthew B.1, 著者Meyers, Jacquelyn L.1, 著者Milaneschi, Yuri1, 著者Palviainen, Teemu1, 著者Pearson, John F.1, 著者Peterson, Roseann E.1, 著者Ripatti, Samuli1, 著者Ryu, Euijung1, 著者Saccone, Nancy L.1, 著者Salvatore, Jessica E.1, 著者Sanchez-Roige, Sandra1, 著者Schwandt, Melanie1, 著者Sherva, Richard1, 著者Streit, Fabian1, 著者Strohmaier, Jana1, 著者Thomas, Nathaniel1, 著者Wang, Jen-Chyong1, 著者Webb, Bradley T.1, 著者Wedow, Robbee1, 著者Wetherill, Leah1, 著者Wills, Amanda G.1, 著者Boardman, Jason D.1, 著者Chen, Danfeng1, 著者Choi, Doo-Sup1, 著者Copeland, William E.1, 著者Culverhouse, Robert C.1, 著者Dahmen, Norbert1, 著者Degenhardt, Louisa1, 著者Domingue, Benjamin W.1, 著者Elson, Sarah L.1, 著者Frye, Mark A.1, 著者Gaebel, Wolfgang1, 著者Hayward, Caroline1, 著者Ising, Marcus2, 著者           Keyes, Margaret1, 著者Kiefer, Falk1, 著者Kramer, John1, 著者Kuperman, Samuel1, 著者Lucae, Susanne2, 著者           Lynskey, Michael T.1, 著者Maier, Wolfgang1, 著者Mann, Karl1, 著者Mannisto, Satu1, 著者Müller-Myhsok, Bertram3, 著者           Murray, Alison D.1, 著者Nurnberger, John I.1, 著者Palotie, Aarno1, 著者Preuss, Ulrich1, 著者Raikkonen, Katri1, 著者Reynolds, Maureen D.1, 著者Ridinger, Monika1, 著者Scherbaum, Norbert1, 著者Schuckit, Marc A.1, 著者Soyka, Michael1, 著者Treutlein, Jens1, 著者Witt, Stephanie1, 著者Wodarz, Norbert1, 著者Zill, Peter1, 著者Adkins, Daniel E.1, 著者Boden, Joseph M.1, 著者Boomsma, Dorret I.1, 著者Bierut, Laura J.1, 著者Brown, Sandra A.1, 著者Bucholz, Kathleen K.1, 著者Cichon, Sven1, 著者Costello, E. Jane1, 著者De Wit, Harriet1, 著者Diazgranados, Nancy1, 著者Dick, Danielle M.1, 著者Eriksson, Johan G.1, 著者Farrer, Lindsay A.1, 著者Foroud, Tatiana M.1, 著者Gillespie, Nathan A.1, 著者Goate, Alison M.1, 著者Goldman, David1, 著者Grucza, Richard A.1, 著者Hancock, Dana B.1, 著者Harris, Kathleen Mullan1, 著者Heath, Andrew C.1, 著者Hesselbrock, Victor1, 著者Hewitt, John K.1, 著者Hopfer, Christian J.1, 著者Horwood, John1, 著者Iacono, William1, 著者Johnson, Eric O.1, 著者Kaprio, Jaakko A.1, 著者Karpyak, Victor M.1, 著者Kendler, Kenneth S.1, 著者Kranzler, Henry R.1, 著者Krauter, Kenneth1, 著者Lichtenstein, Paul1, 著者Lind, Penelope A.1, 著者McGue, Matt1, 著者MacKillop, James1, 著者Madden, Pamela A. F.1, 著者Maes, Hermine H.1, 著者Magnusson, Patrik1, 著者Martin, Nicholas G.1, 著者Medland, Sarah E.1, 著者Montgomery, Grant W.1, 著者Nelson, Elliot C.1, 著者Noethen, Markus M.1, 著者Palmer, Abraham A.1, 著者Pedersen, Nancy L.1, 著者Penninx, Brenda W. J. H.1, 著者Porjesz, Bernice1, 著者Rice, John P.1, 著者Rietschel, Marcella1, 著者Riley, Brien P.1, 著者Rose, Richard1, 著者Rujescu, Dan1, 著者Shen, Pei-Hong1, 著者Silberg, Judy1, 著者Stallings, Michael C.1, 著者Tarter, Ralph E.1, 著者Vanyukov, Michael M.1, 著者Vrieze, Scott1, 著者Wall, Tamara L.1, 著者Whitfield, John B.1, 著者Zhao, Hongyu1, 著者Neale, Benjamin M.1, 著者Gelernter, Joel1, 著者Edenberg, Howard J.1, 著者Agrawal, Arpana1, 著者 全て表示
所属:
1External Organizations, ou_persistent22              
2Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              
3RG Statistical Genetics, Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2040288              

内容説明

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キーワード: GENOME-WIDE ASSOCIATION; NATIONAL EPIDEMIOLOGIC SURVEY; LD SCORE REGRESSION; RISK; METAANALYSIS; HERITABILITY; CONSUMPTION; ADH1B; PARTICIPANTS; COMORBIDITYNeurosciences & Neurology;
 要旨: Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest genome-wide association study to date of DSM-IV-diagnosed AD. Genome-wide data on 14,904 individuals with AD and 37,944 controls from 28 case-control and family-based studies were meta-analyzed, stratified by genetic ancestry (European, n = 46,568; African, n = 6,280). Independent, genome-wide significant effects of different ADH1B variants were identified in European (rs1229984; P = 9.8 x 10(-13)) and African ancestries (rs2066702; P = 2.2 x 10(-9)). Significant genetic correlations were observed with 17 phenotypes, including schizophrenia, attention deficit-hyperactivity disorder, depression, and use of cigarettes and cannabis. The genetic underpinnings of AD only partially overlap with those for alcohol consumption, underscoring the genetic distinction between pathological and nonpathological drinking behaviors.

資料詳細

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言語: eng - English
 日付: 2018
 出版の状態: 出版
 ページ: 16
 出版情報: -
 目次: -
 査読: -
 識別子（DOI, ISBNなど）: ISI: 000451324700005
DOI: 10.1038/s41593-018-0275-1
 学位: -

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出版物 1

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出版物名: NATURE NEUROSCIENCE
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA : NATURE PUBLISHING GROUP
ページ: - 巻号: 21 (12) 通巻号: - 開始・終了ページ: 1656 - 1669 識別子（ISBN, ISSN, DOIなど）: ISSN: 1097-6256