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  Evidence against co-storage of enkephalins with noradrenaline in bovine adrenal medullary granules

Lang, R. E., Taugner, G., Gaida, W., Ganten, D., Kraft, K., Unger, T., et al. (1982). Evidence against co-storage of enkephalins with noradrenaline in bovine adrenal medullary granules. European Journal of Pharmacology, 86(1), 117-120. doi:10.1016/0014-2999(82)90408-3.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-6C61-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-6C62-6
Genre: Journal Article

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EurJPharmacol_86_1983_117.pdf (Any fulltext), 250KB
 
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 Creators:
Lang, R. E., Author
Taugner, G.1, Author              
Gaida, W., Author
Ganten, D., Author
Kraft, K., Author
Unger, Th., Author
Wunderlich, Ilse2, Author              
Affiliations:
1Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              
2Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

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 Abstract: Bovine adrenal chromaffin granules were purified and separated into adrenaline (A) and noradrenaline (NA) containing granule populations by a combination of differential and isopycnic gradient centrifugation. The distribution of [Leu5]enkephalin as measured by radioimmunoassay followed a pattern identical to adrenaline but not noradrenaline on centrifugation. This suggests that enkephalins are stored in the same type of granule where adrenaline is found or that enkephalins and adrenaline even coexist in one and the same granule. Enkephalins may therefore function as co-transmitters or co-hormones of adrenaline rather than noradrenaline in the adrenal medulla.

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Language(s): eng - English
 Dates: 1982-08-091982-10-212002-11-201982-12-17
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
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Title: European Journal of Pharmacology
  Other : European Journal of Pharmacology
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 86 (1) Sequence Number: - Start / End Page: 117 - 120 Identifier: ISSN: 0014-2999
CoNE: https://pure.mpg.de/cone/journals/resource/954925398488